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. 2021 Feb;6(2):103-106.
doi: 10.1038/s41578-020-00277-6. Epub 2021 Jan 7.

Extracellular vesicles versus synthetic nanoparticles for drug delivery

Kenneth W Witwer  1   2 , Joy Wolfram  3   4   5
Affiliations

Extracellular vesicles versus synthetic nanoparticles for drug delivery

Kenneth W Witwer et al. Nat Rev Mater. 2021 Feb.

Abstract

Cell-released biological nanoparticles, including extracellular vesicles (EVs), are emerging drug carriers with high complexity. EV-based drug delivery has the potential to efficiently exploit intrinsic mechanisms for molecular transport in the body. Integrating the expanding knowledge of EV biology and manufacturing with clinical insights from synthetic nanoparticles is likely to substantially advance the field of drug delivery.

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Figures

Figure 1.
Figure 1.. Characteristics of free drugs, clinically approved synthetic nanoparticles and extracellular vesicles.
Low (+), medium (++), and high (+++).
See this image and copyright information in PMC

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