Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2022 Sep 2:12:998313.
doi: 10.3389/fcimb.2022.998313. eCollection 2022.

The impact of periodontitis on vascular endothelial dysfunction

Qian Li  1 , Xiangying Ouyang  2 , Jiang Lin  1
Affiliations
Review

The impact of periodontitis on vascular endothelial dysfunction

Qian Li et al. Front Cell Infect Microbiol. .

Abstract

Periodontitis, an oral inflammatory disease, originates from periodontal microbiota dysbiosis which is associated with the dysregulation of host immunoinflammatory response. This chronic infection is not only harmful to oral health but is also a risk factor for the onset and progress of various vascular diseases, such as hypertension, atherosclerosis, and coronary arterial disease. Vascular endothelial dysfunction is the initial key pathological feature of vascular diseases. Clarifying the association between periodontitis and vascular endothelial dysfunction is undoubtedly a key breakthrough for understanding the potential relationship between periodontitis and vascular diseases. However, there is currently a lack of an updated review of their relationship. Therefore, we aim to focus on the implications of periodontitis in vascular endothelial dysfunction in this review.

Keywords: Porphyromonas gingivalis; periodontitis; vascular disease; vascular endothelial cells; vascular endothelial dysfunction.

PubMed Disclaimer

Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The handling editor ZW declared a shared parent affiliation with the authors QL and JL at the time of review.

Figures

Figure 1
Figure 1
The potential pathways periodontitis induces vascular endothelial dysfunction.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Abusleme L., Hoare A., Hong B. Y., Diaz P. I. (2021). Microbial signatures of health, gingivitis, and periodontitis. Periodontol. 2000. 86, 57–78. doi: 10.1111/prd.12362 - DOI - PubMed
    1. Ambrosino P., Papa A., Buonauro A., Mosella M., Calcaterra I., Spedicato G. A., et al. . (2021). Clinical assessment of endothelial function in heart failure with preserved ejection fraction: A meta-analysis with meta-regressions. Eur. J. Clin. Invest. 51, e13552. doi: 10.1111/eci.13552 - DOI - PubMed
    1. An N., Andrukhov O., Tang Y., Falkensammer F., Bantleon H. P., Ouyang X., et al. . (2014). Effect of nicotine and porphyromonas gingivalis lipopolysaccharide on endothelial cells in vitro . PLoS. One 9, e96942. doi: 10.1371/journal.pone.0096942 - DOI - PMC - PubMed
    1. Balta S. (2021). Endothelial dysfunction and inflammatory markers of vascular disease. Curr. Vasc. Pharmacol. 19, 243–249. doi: 10.2174/1570161118666200421142542 - DOI - PubMed
    1. Balta M. G., Papathanasiou E., Blix I. J., Dyke T. (2021). Host modulation and treatment of periodontal disease. J. Dent. Res. 100, 798–809. doi: 10.1177/0022034521995157 - DOI - PMC - PubMed

Publication types