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Review
. 2022 Sep 2:12:998313.
doi: 10.3389/fcimb.2022.998313. eCollection 2022.

The impact of periodontitis on vascular endothelial dysfunction

Qian Li  1 , Xiangying Ouyang  2 , Jiang Lin  1
Affiliations
Review

The impact of periodontitis on vascular endothelial dysfunction

Qian Li et al. Front Cell Infect Microbiol. .

Abstract

Periodontitis, an oral inflammatory disease, originates from periodontal microbiota dysbiosis which is associated with the dysregulation of host immunoinflammatory response. This chronic infection is not only harmful to oral health but is also a risk factor for the onset and progress of various vascular diseases, such as hypertension, atherosclerosis, and coronary arterial disease. Vascular endothelial dysfunction is the initial key pathological feature of vascular diseases. Clarifying the association between periodontitis and vascular endothelial dysfunction is undoubtedly a key breakthrough for understanding the potential relationship between periodontitis and vascular diseases. However, there is currently a lack of an updated review of their relationship. Therefore, we aim to focus on the implications of periodontitis in vascular endothelial dysfunction in this review.

Keywords: Porphyromonas gingivalis; periodontitis; vascular disease; vascular endothelial cells; vascular endothelial dysfunction.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The handling editor ZW declared a shared parent affiliation with the authors QL and JL at the time of review.

Figures

Figure 1
Figure 1
The potential pathways periodontitis induces vascular endothelial dysfunction.
See this image and copyright information in PMC

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