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. 2022 Sep 8:2022:4887259.
doi: 10.1155/2022/4887259. eCollection 2022.

Efficacy and Safety of Gegen Qinlian Decoction for Pediatric Diarrhea: A Systematic Review and Meta-Analysis

Dan Wang  1 , Chao-Ran Bi  2 , Hai-Yan Jiang  3 , Yi-Jing Li  2 , Wen-Ping Zhang  2 , Yuan Liu  2 , Yan-Jing Liu  1
Affiliations

Efficacy and Safety of Gegen Qinlian Decoction for Pediatric Diarrhea: A Systematic Review and Meta-Analysis

Dan Wang et al. Evid Based Complement Alternat Med. .

Abstract

Objective: To evaluate the clinical efficacy and safety of Gegen Qinlian decoction in the treatment of pediatric diarrhea.

Methods: A search for relevant RCTs was performed from which a systematic review and meta-analysis was conducted. This meta-analysis was registered at INPLASY (reference number ID: INPLASY202180105).

Results: (1) Eleven trials involving 1126 patients were included in the meta-analysis. (2) Two trials recorded the adverse events. (3) The meta-analysis showed that compared with the control group, the experimental group has a significantly shorter duration of diarrhea in children (MD = -18.64, 95% CI (-23.76, -13.52), P < 0.00001), duration of fever (MD = -19.43, 95% CI (-25.76, -13.11), P < 0.00001), duration of vomiting [MD = -22.51, 95% CI (-29.92, -15.09), P < 0.00001], duration of correcting dehydration (MD = -23.35, 95% CI (-35.48, -11.22), P=0.0002), and the effective rate (OR = 4.64, 95% CI (3.12, 6.90), P < 0.00001).

Conclusion: There were significant differences in the clinical efficacy in the treatment of pediatric diarrhea between the experimental and control groups. Thus, Gegen Qinlian decoction may have certain advantages in the treatment of pediatric diarrhea. In addition, we conclude the following: (1) the application of Gegen Qinlian decoction to treat this disease is recommended for >5 days. (2) We recommend conducting multicenter RCTs to avoid the impact of regional differences on the results. (3) We recommend using the unmodified Gegen Qinlian decoction, which may have better efficacy.

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Conflict of interest statement

The authors declare that there are no conflicts of interest regarding the publication of this article.

Figures

Figure 1
Figure 1
Flow diagram of RCT selection.
Figure 2
Figure 2
The risk of bias summary graph for the 11 included studies.
Figure 3
Figure 3
Forest plot and meta-analysis of the diarrhea duration.
Figure 4
Figure 4
Forest plot and meta-analysis of the fever duration.
Figure 5
Figure 5
Forest plot and meta-analysis of the vomiting duration.
Figure 6
Figure 6
Forest plot and meta-analysis of the time to correct dehydration.
Figure 7
Figure 7
Forest plot and meta-analysis of the total effective rate.
Figure 8
Figure 8
Funnel plot of the effective rate.
See this image and copyright information in PMC

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