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. 2022 Sep 5:2022:4853481.
doi: 10.1155/2022/4853481. eCollection 2022.

Analysis of the Relationship between Scleritis and T Cell Activation in Patients with Hepatocellular Carcinoma Treated with PD-1 Carrelizumab

Yazhen Yuan  1 , Shuaixi Pan  2 , Changpeng Zou  3 , Yan Guo  3 , Changwang Zhang  3 , Zheng Zheng  3 , Ninghan Wu  4 , Na Li  3
Affiliations

Analysis of the Relationship between Scleritis and T Cell Activation in Patients with Hepatocellular Carcinoma Treated with PD-1 Carrelizumab

Yazhen Yuan et al. Contrast Media Mol Imaging. .

Retraction in

Abstract

In order to explore the function of inhibiting the immune effect, the relationship between programmed death receptor 1 (PD-1) carrelizumab in the treatment of hepatocellular carcinoma-induced scleritis and T cell activation is investigated. A total of 120 patients with primary liver cancer treated in the department of oncology of our hospital from July 2020 to January 2022 are selected and treated with carrelizumab. According to the occurrence of PD-1 carrelizumab treatment, the patients are divided into the scleritis group and nonscleritis group. The levels of T cells, PD-1, PD-L1 proteins, and serum inflammatory factors at different time points are compared. The experimental results show that the occurrence of scleritis after liver cancer treatment with PD-1 carrelizumab is closely associated with Treg cells, the percentage of Th17 cells, the expression of PD-1, PD-L1 proteins, and inflammatory factors. It is clearly evident that PD-1 carrelizumab can increase the risk of scleritis by affecting T cell activation.

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Conflict of interest statement

The authors declare that there are no conflicts of interest.

Figures

Figure 1
Figure 1
Percentage changes of Treg cells and Th17 cells.
Figure 2
Figure 2
Protein expression differences between PD-1 and PD-L1.
Figure 3
Figure 3
Changes in the expression of inflammatory factors.
See this image and copyright information in PMC

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