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. 2022 Sep 2:12:858151.
doi: 10.3389/fonc.2022.858151. eCollection 2022.

A high preoperative serum IL-25 level is a negative prognosis predictor after liver resection for HBV-HCC

Shao-Hua Chen  1 , Xu Wang  2
Affiliations

A high preoperative serum IL-25 level is a negative prognosis predictor after liver resection for HBV-HCC

Shao-Hua Chen et al. Front Oncol. .

Abstract

Objective: The aim of this study was to evaluate the association between preoperative IL-25 levels and HBV-HCC patient outcomes following liver surgery.

Methods: This study enrolled consecutive HCC patients that had undergone liver surgery from 2008 to 2015. Baseline patient clinical properties were assessed to establish predictors of postoperative overall survival and recurrence-free survival (OS and RFS, respectively) following liver resection. In addition, serum IL-25 levels were assessed via ELISA.

Results: Cox regression analyses revealed IL-25 levels to be independently related to the OS and RFS of 896 HBV-associated HCC patients. An optimal IL-25 cutoff level of 14.9 μg/ml was identified, with 206 patients in this cohort having IL-25 levels above this threshold. Both the OS and RFS of patients with an IL-25 level <14.9 μg/ml were significantly better after liver resection as compared to those of patients with higher preoperative levels of this cytokine (p < 0.05). Cox multivariate regression analyses revealed an IL-25 level ≥ 14.9 μg/L to be an independent predictor of poorer RFS and OS. A combination of IL-25 levels and tumor diameter may be an even more reliable predictor of OS.

Conclusions: IL-25 levels are independent predictors of postoperative survival within HCC patients undergoing liver resection.

Keywords: IL-25; biomarker; hepatitis B virus; hepatocellular carcinoma; prognosis.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
Study population selection.
Figure 2
Figure 2
Assessments of the receiver operating characteristic (ROC) curve for the specificity and sensitivity of IL-25 in HCC patients.
Figure 3
Figure 3
(A, B) RFS (A) and OS (B) curves for all 896 HCC patients with low or high IL-25 levels. (C) Curves of RFS for HCC patients in the PSM cohort with low or high IL-25 levels. (D) Curves of OS for HCC patients in the PSM cohort with low or high IL-25 levels.
Figure 4
Figure 4
HCC patient survival nomogram. (A, B) A survival nomogram designed to assess HCC patient RFS (A) and OS (B).
See this image and copyright information in PMC

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