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. 2022;52(5):722-738.
doi: 10.1007/s11055-022-01297-1. Epub 2022 Sep 14.

Effects of Social Isolation on the Development of Anxiety and Depression-Like Behavior in Model Experiments in Animals

G A Grigoryan  1 , I V Pavlova  1 , M I Zaichenko  1
Affiliations

Effects of Social Isolation on the Development of Anxiety and Depression-Like Behavior in Model Experiments in Animals

G A Grigoryan et al. Neurosci Behav Physiol. 2022.

Abstract

This review describes the role of social isolation in the development of anxiety and depression-like behavior in rodents. The duration of social isolation, age from onset of social isolation, sex, species, and strain of animals, the nature of the model used, and other factors have been shown to have influences. The molecular-cellular mechanisms of development of anxiety and depression-like behavior under the influence of social isolation and the roles of the HHAS, oxidative and nitrosative stress, neuroinflammation, BDNF, neurogenesis, synaptic plasticity, as well as monoamines in these mechanisms are discussed. This review presents data on sex differences in the effects of social isolation, along with the effects of interactions with other types of stress, and the roles of an enriched environment and other factors in ameliorating the negative sequelae of social isolation.

Keywords: anxiety and depression-like behavior; elevated plus maze; forced swimming; open field; social isolation; stress; sucrose preference test.

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