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. 2022 Dec;7(12):2714-2717.
doi: 10.1016/j.ekir.2022.09.003. Epub 2022 Sep 12.

A Randomized Control Trial of Ravulizumab for Treatment of Patients With COVID-19 Infection and Kidney Injury

Aliza A Memon  1 , Hasban Ahmed  2 , Yi Li  2 , Janewit Wongboonsin  2 , Joshua Hundert  3 , Stefanie Benoit  4 , Advika Chaudhari  5 , Jawad Sher  6 , Pratima Ghimire  7 , Rebecca Hopkins  4 , Jay Patel  4 , Melinda Stegman  4 , Kenneth Lim  6 , Jamil Azzi  2 , Andrew M Siedlecki  2
Affiliations

A Randomized Control Trial of Ravulizumab for Treatment of Patients With COVID-19 Infection and Kidney Injury

Aliza A Memon et al. Kidney Int Rep. 2022 Dec.
No abstract available

Keywords: COVID19; SARS-CoV2; acute kidney injury; hemodialysis; thrombotic microangiopathy.

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Figures

Figure 1
Figure 1
Ravulizumab treatment measures in patients diagnosed with COVID-19-Associated AKI. (a) Serum ravulizumab levels in 6 enrolled patients, mean value over 60 days (solid red line), and mean 30-day area under the curve [circumscribed red dotted line] after enrollment, (b) Free C5 serum levels in 6 enrolled patients with corresponding serum ravulizumab levels, soluble ICAM-1, and soluble C5b-9 levels, (c) Platelet counts in patients receiving [i] standard of care and ravulizumab (SOC+R) compared to [ii] SOC alone for 30 days after enrollment, (d) Days of anuria in [i] SOC+R and [ii] SOC for 30 days after enrollment [black arrow = patient death], (e) 5-day mean daily dialysis frequency in SOC+R (red) vs. SOC (black) after enrollment (arrows = patient death), (f) Serial World Health Organization severity classification SOC+R (red) vs. SOC (black) and corresponding Kaplan Meier survival curve (SOC+R = solid line, SOC = dotted line). C5, component 5 protein; ICAM-1, intercellular adhesion molecule 1; SOC, standard of care.
See this image and copyright information in PMC

References

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