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. 2022 Sep 2:13:968766.
doi: 10.3389/fendo.2022.968766. eCollection 2022.

Cardiovascular and renal burdens among patients with MAFLD and NAFLD in China

Yuying Wang  1 , Yuetian Yu  1 , Haojie Zhang  1 , Chi Chen  1 , Heng Wan  1 , Yi Chen  1 , Fangzhen Xia  1 , Shiyan Yu  1 , Ningjian Wang  1 , Lin Ye  1 , Yingli Lu  1
Affiliations

Cardiovascular and renal burdens among patients with MAFLD and NAFLD in China

Yuying Wang et al. Front Endocrinol (Lausanne). .

Abstract

Background/purpose: Metabolic associated fatty liver disease (MAFLD) was proposed as a new definition to put emphasis on the metabolic aspects of nonalcoholic fatty liver disease (NAFLD). We aim to compare the cardiovascular and renal burden between MAFLD and NAFLD patients.

Methods: 12183 participants were enrolled in East China. The cardiovascular burden (Framingham risk score and previous cardiovascular diseases (CVD)) and renal burden (eGFR and chronic kidney disease (CKD)) were measured.

Results: The risk of hypertension, dyslipidemia, diabetes, overweight/obesity, and central obesity of MAFLD patients were higher than those of NAFLD. Patients with MAFLD have a similar or higher beta coefficients in Framingham risk score [beta (95%CI): male 0.062 (0.055,0.069) vs 0.041 (0.033,0.048); female 0.014 (0.012,0.016) vs 0.012 (0.01,0.014)], and higher odds ratio in previous CVD [odds ratio (95%CI): male 1.50 (1.22,1.85) vs 1.35 (1.1,1.66); female 1.58 (1.33,1.87) vs 1.45 (1.22,1.72)], compared with those with NAFLD. However, compared with males with MAFLD, the odds ratio of CKD was higher in those with NAFLD [eGFR: -2.731 (-3.422, -2.041) vs-3.578 (-4.268, -2.887). CKD: 1.44 (1.05,1.96) vs 1.56 (1.14,2.12)]. In female, CKD was only marginally associated with NAFLD [0.8 (0.62,1.02), P=0.075], but not MAFLD [0.87 (0.68,1.11), P=0.268].

Conclusions: Patients with MAFLD have a similar or higher risk of future and previous CVD compared with those with NAFLD, but the risk of CKD was higher in male with NAFLD.

Keywords: CKD; CVD; China; MAFLD; NAFLD.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
The inclusion and exclusion criteria of the study participants.
Figure 2
Figure 2
Burden of MAFLD and NAFLD on CVD and CKD. Data are expressed as OR/B (95% CI). All analyses were adjusted for age and current smoking.
See this image and copyright information in PMC

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