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. 2022 Nov;117(11):1332-1344.
doi: 10.1111/vox.13361. Epub 2022 Sep 19.

International Society of Blood Transfusion Working Party on Red Cell Immunogenetics and Blood Group Terminology Report of Basel and three virtual business meetings: Update on blood group systems

Christoph Gassner  1 , Lilian Castilho  2 , Qing Chen  3 , Frederik Banch Clausen  4 , Gregory A Denomme  5 , Willy A Flegel  6 , Nick Gleadall  7 , Åsa Hellberg  8 , Yanli Ji  9 , Margaret A Keller  10 , William J Lane  11 , Peter Ligthart  12 , Christine Lomas-Francis  13 , Nuria Nogues  14 , Martin L Olsson  8   15 , Thierry Peyrard  16   17 , Jill R Storry  8   15 , Yoshihiko Tani  18 , Nicole Thornton  19 , Ellen van der Schoot  20 , Barbera Veldhuisen  12   20 , Franz Wagner  21   22 , Christof Weinstock  23 , Silvano Wendel  24 , Connie Westhoff  13 , Vered Yahalom  25 , Catherine A Hyland  26
Affiliations

International Society of Blood Transfusion Working Party on Red Cell Immunogenetics and Blood Group Terminology Report of Basel and three virtual business meetings: Update on blood group systems

Christoph Gassner et al. Vox Sang. 2022 Nov.

Abstract

Background and objectives: Under the ISBT, the Working Party (WP) for Red Cell Immunogenetics and Blood Group Terminology is charged with ratifying blood group systems, antigens and alleles. This report presents the outcomes from four WP business meetings, one located in Basel in 2019 and three held as virtual meetings during the COVID-19 pandemic in 2020 and 2021.

Materials and methods: As in previous meetings, matters pertaining to blood group antigen nomenclature were discussed. New blood group systems and antigens were approved and named according to the serologic, genetic, biochemical and cell biological evidence presented.

Results: Seven new blood group systems, KANNO (defined numerically as ISBT 037), SID (038), CTL2 (039), PEL (040), MAM (041), EMM (042) and ABCC1 (043) were ratified. Two (039 and 043) were de novo discoveries, and the remainder comprised reported antigens where the causal genes were previously unknown. A further 15 blood group antigens were added to the existing blood group systems: MNS (002), RH (004), LU (005), DI (010), SC (013), GE (020), KN (022), JMH (026) and RHAG (030).

Conclusion: The ISBT now recognizes 378 antigens, of which 345 are clustered within 43 blood group systems while 33 still have an unknown genetic basis. The ongoing discovery of new blood group systems and antigens underscores the diverse and complex biology of the red cell membrane. The WP continues to update the blood group antigen tables and the allele nomenclature tables. These can be found on the ISBT website (http://www.isbtweb.org/working-parties/red-cell-immunogenetics-and-blood-group-terminology/).

Keywords: blood groups; genetics; genomics; red cell antigens; terminology.

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Conflict of interest statement

CONFLICT OF INTEREST

C.G. acts as a consultant to inno-train Diagnostik GmbH, Kronberg i. T., Germany. Procedures for the molecular detection of GYPB deletions for S-s-U- phenotype diagnostics have been granted as a European patent (EP 3 545 102 B1). A similar content patent US application is pending. G.A.D. is a transfusion education consultant for Abbott Laboratories, Chicago, IL. W.J.L. is a member of the Scientific Advisory Board of CareDx, Inc. and his institution is a founding member of the Blood Transfusion Genomics Consortium (BGC) that has received fees from Thermo Fisher Scientific Inc. to help co-develop a high-density DNA genotyping array. C.M.W. is a member of the Scientific Advisory Board of Quotient. N.G., M.L.O. and J.R.S. have no conflicts of interest with regard to this manuscript. L.C., Q.C., F.B.C., W.A.F., A.H., J.Y., M.A.K., P.L., C.L.F., N.N., T.P., Y.T., N.T., E.V.D.S., B.V., F.F.W., C.W., S.W., V.Y. and C.H. have no conflicts of interest.

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