Comment

. 2023 Jan;50(2):453-464.

doi: 10.1007/s00259-022-05962-y. Epub 2022 Sep 19.

Early detection of radiation-induced myocardial damage by [¹⁸F]AlF-NOTA-FAPI-04 PET/CT imaging

Yuchun Wei¹, Yuhong Sun², Junyan Liu³, Gongsen Zhang⁴, Xueting Qin¹, Shengnan Xu⁴, Shijie Wang⁴, Yuanyuan Tao¹, Jinli Pei⁵, Jinming Yu^{6

7}

Affiliations

¹ Department of Radiology, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, 250117, Shandong, China.
² Department of Pathology, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, Shandong, China.
³ Department of Internal Medicine-Oncology, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, Shandong, China.
⁴ Department of Radiation Oncology and Shandong Provincial Key Laboratory of Radiation Oncology, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, 250117, Shandong, China.
⁵ Department of Radiation Oncology and Shandong Provincial Key Laboratory of Radiation Oncology, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, 250117, Shandong, China. peijinli609@163.com.
⁶ Department of Radiology, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, 250117, Shandong, China. sdyujinming@163.com.
⁷ Department of Radiation Oncology and Shandong Provincial Key Laboratory of Radiation Oncology, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, 250117, Shandong, China. sdyujinming@163.com.

PMID: 36121463
DOI: 10.1007/s00259-022-05962-y

Comment

Early detection of radiation-induced myocardial damage by [¹⁸F]AlF-NOTA-FAPI-04 PET/CT imaging

Yuchun Wei et al. Eur J Nucl Med Mol Imaging. 2023 Jan.

. 2023 Jan;50(2):453-464.

doi: 10.1007/s00259-022-05962-y. Epub 2022 Sep 19.

Authors

Yuchun Wei¹, Yuhong Sun², Junyan Liu³, Gongsen Zhang⁴, Xueting Qin¹, Shengnan Xu⁴, Shijie Wang⁴, Yuanyuan Tao¹, Jinli Pei⁵, Jinming Yu^{6

7}

Affiliations

¹ Department of Radiology, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, 250117, Shandong, China.
² Department of Pathology, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, Shandong, China.
³ Department of Internal Medicine-Oncology, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, Shandong, China.
⁴ Department of Radiation Oncology and Shandong Provincial Key Laboratory of Radiation Oncology, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, 250117, Shandong, China.
⁵ Department of Radiation Oncology and Shandong Provincial Key Laboratory of Radiation Oncology, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, 250117, Shandong, China. peijinli609@163.com.
⁶ Department of Radiology, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, 250117, Shandong, China. sdyujinming@163.com.
⁷ Department of Radiation Oncology and Shandong Provincial Key Laboratory of Radiation Oncology, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, 250117, Shandong, China. sdyujinming@163.com.

PMID: 36121463
DOI: 10.1007/s00259-022-05962-y

Abstract

Purpose: Retrospective analysis revealed increased [¹⁸F]AlF-NOTA-FAPI-04 uptake in the myocardium of patients with esophageal squamous cell cancer (ESCC) treated with concurrent chemoradiotherapy (CCRT). This study investigated and verified the feasibility of [¹⁸F]AlF-NOTA-FAPI-04 PET/CT for detecting radiation-induced myocardial damage (RIMD).

Methods: Myocardial FAPI uptake was analyzed before and during radiotherapy in thirteen ESCC patients treated with CCRT. In the animal study, a single dose of 50 Gy was delivered to the cardiac apex of Wistar rats (24 rats, including 16 RIMD model rats and 8 control model rats). RIMD model rats were scanned with [¹⁸F]AlF-NOTA-FAPI-04 PET/CT weekly for 12 weeks, and left ventricular ejection fraction (LVEF) was measured by magnetic resonance imaging. Dynamic, blocking, and [¹⁸F]FDG PET/CT studies (4 rats/group) were performed on RIMD rats at 5 weeks post-radiation, and histopathological analyses were conducted.

Results: Increased FAPI uptake in the myocardium was found after CCRT (1.53 ± 0.53 vs 1.88 ± 0.70, P = 0.015). In RIMD rats, significantly increased FAPI uptake in the damaged myocardium was observed from the 2nd week post-radiation exposure and peaked in the 5th week. Significantly more intense tracer accumulation was observed in the damaged myocardium than in the remote myocardium, as identified by decreased [¹⁸F]FDG uptake and confirmed by autoradiography, hematoxylin-eosin, Masson's trichrome, and immunohistochemical staining. The LVEF remained unchanged at the 3rd week post-radiation exposure but was remarkably decreased compared with that in the control group at the 8th week.

Conclusion: Through clinical phenomena and animal experimental studies, this study indicated that [¹⁸F]AlF-NOTA-FAPI-04 PET/CT imaging can detect RIMD noninvasively and before a decrease in LVEF, indicating the clinical potential of [¹⁸F]AlF-NOTA-FAPI-04 as a PET/CT tracer for early monitoring of RIMD.

Keywords: Fibroblast activation protein; PET/CT; Radiation-induced heart damage.

PubMed Disclaimer

Comment on

Cardiac fibroblast activation detected by Ga-68 FAPI PET imaging as a potential novel biomarker of cardiac injury/remodeling.
Siebermair J, Köhler MI, Kupusovic J, Nekolla SG, Kessler L, Ferdinandus J, Guberina N, Stuschke M, Grafe H, Siveke JT, Kochhäuser S, Fendler WP, Totzeck M, Wakili R, Umutlu L, Schlosser T, Rassaf T, Rischpler C. Siebermair J, et al. J Nucl Cardiol. 2021 Jun;28(3):812-821. doi: 10.1007/s12350-020-02307-w. Epub 2020 Sep 25. J Nucl Cardiol. 2021. PMID: 32975729 Free PMC article.

References

1. Yu AF, Ho AY, Braunstein LZ, Thor ME, Lee CK, Eaton A, et al. Assessment of early radiation-induced changes in left ventricular function by myocardial strain imaging after breast radiation therapy. J Am Soc Echocardiogr. 2019;32:521–8. - DOI
1. Beukema JC, van Luijk P, Widder J, Langendijk JA, Muijs CT. Is cardiac toxicity a relevant issue in the radiation treatment of esophageal cancer. Radiother Oncol. 2015;114:85–90. - DOI
1. Beukema JC, de Groot C, Plukker JTM, Vliegenthart R, Langendijk JA, van Luijk P, et al. Late cardiac toxicity of neo-adjuvant chemoradiation in esophageal cancer survivors: a prospective cross-sectional pilot study. Radiother Oncol. 2022;167:72–7. - DOI
1. Dess RT, Sun Y, Matuszak MM, Sun G, Soni PD, Bazzi L, et al. Cardiac events after radiation therapy: combined analysis of prospective multicenter trials for locally advanced non-small-cell lung cancer. J Clin Oncol. 2017;35:1395–402. - DOI
1. Speirs CK, DeWees TA, Rehman S, Molotievschi A, Velez MA, Mullen D, et al. Heart dose is an independent dosimetric predictor of overall survival in locally advanced non-small cell lung cancer. J Thorac Oncol. 2017;12:293–301. - DOI

Publication types

Actions

MeSH terms

Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions

Substances

Actions
Actions
Actions
Actions
Actions

Grants and funding

LinkOut - more resources

Full Text Sources
- Springer
Medical
- MedlinePlus Health Information
Miscellaneous
- NCI CPTAC Assay Portal

Save citation to file

Email citation

Add to Collections

Add to My Bibliography

Your saved search

Create a file for external citation management software

Your RSS Feed

Early detection of radiation-induced myocardial damage by [¹⁸F]AlF-NOTA-FAPI-04 PET/CT imaging

Affiliations

Early detection of radiation-induced myocardial damage by [¹⁸F]AlF-NOTA-FAPI-04 PET/CT imaging

Authors

Affiliations

Abstract

Comment on

References

Publication types

MeSH terms

Substances

Grants and funding

LinkOut - more resources

Full Text Sources

Medical

Miscellaneous