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Review
. 2022 Nov;55(7):553-557.
doi: 10.1007/s00391-022-02107-6. Epub 2022 Sep 19.

[Aging of the immune system]

[Article in German]
Anne Großkopf  1 , Andreas Simm  2
Affiliations
Review

[Aging of the immune system]

[Article in German]
Anne Großkopf et al. Z Gerontol Geriatr. 2022 Nov.

Abstract
in English, German

With increasing age a rise in the incidence of infections, inflammatory diseases such as arteriosclerosis and tumors and simultaneously a reduction in the success of vaccinations can be observed. A dysfunctional immune system is responsible for this. The immune system can be divided into three domains. The first barrier, the epithelioid protective barrier of the skin and the mucosa, loses its protective function with age. The second barrier, the innate immune system, is characterized in old age by chronic low-grade inflammation and a simultaneous reduction of an adequate response to pathogens. The reduced hematopoiesis of new naïve lymphocytes and a reduction of diversity describe the adaptive immune system, the third barrier at old age. These changes, summarized as immunosenescence, are partly responsible for many degenerative diseases.

Mit zunehmendem Alter sind ein Anstieg der Inzidenz von Infektionen, inflammatorischen Erkrankungen, wie Arteriosklerose, und Tumoren sowie parallel eine Reduktion des Impferfolgs zu beobachten. Dafür ist ein dysfunktionelles Immunsystem verantwortlich. Das Immunsystem kann in 3 Bereiche eingeteilt werden. Die erste Barriere, die epitheloide Schutzschicht der Haut und der Schleimhäute, verliert mit dem Alter ihre Schutzfunktion. Die zweite Barriere, das angeborene Immunsystem, wird im Alter durch eine chronische niedriggradige Entzündung bei gleichzeitiger Reduktion einer adäquaten Antwort auf Pathogene charakterisiert. Die reduzierte Bildung neuer naiver Lymphozyten und eine Abnahme der Diversität kennzeichnen das adaptive Immunsystem, die dritte Barriere, im Alter. Diese als Immunseneszenz zusammengefassten Veränderungen sind für eine Vielzahl von degenerativen Erkrankungen mitverantwortlich.

Keywords: Barrier function; Cytokines; Frailty; Immunosenescence; Inflammaging.

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