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Review

Lymphodepleting Conditioning Regimens

Mohamad Mohty  1 , Monique C. Minnema  2
Nicolaus Kröger  1 , John Gribben  2 , Christian Chabannon  3 , Ibrahim Yakoub-Agha  4 , Hermann Einsele  5
, editors.
In: The EBMT/EHA CAR-T Cell Handbook [Internet]. Cham (CH): Springer; 2022. Chapter 25.
.
Affiliations
Review

Lymphodepleting Conditioning Regimens

Mohamad Mohty et al.

Excerpt

Lymphodepleting conditioning regimens are essential for the success of CAR-T cell treatment. Their importance in the proliferation and persistence of CAR-T cells has become clearer in the recent years. The suggested mechanisms are described in Table 25.1 and include the effects on immune cells and cytokines, creating an environment for optimal functioning and increasing the peak of expansion of the infused CAR-T cells (Neelapu 2019).

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References

    1. Hirayama AV, Gauthier J, Hay KA, et al. The response to lymphodepletion impacts PFS in patients with aggressive non-Hodgkin lymphoma treated with CD19 CAR-T cells. Blood. 2019;133:1876–87. - PMC - PubMed
    1. Neelapu SS. CAR-T efficacy: is conditioning the key? Blood. 2019;133:1799–800. - PubMed
    1. Turtle CJ, Hanafi L-A, Berger C, et al. Immunotherapy of non-Hodgkin’s lymphoma with a defined ratio of CD8+ and CD4+ CD19-specific chimeric antigen receptor–modified T cells. Sci Transl Med. 2016;8:1–12. - PMC - PubMed