Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review

Metabolism of Triglyceride-Rich Lipoproteins

Jan Borén  1   2 , Marja-Riitta Taskinen  3
Arnold von Eckardstein  1 , Christoph J. Binder  2
, editors.
In: Prevention and Treatment of Atherosclerosis: Improving State-of-the-Art Management and Search for Novel Targets [Internet]. Cham (CH): Springer; 2022.
.
Affiliations
Free Books & Documents
Review

Metabolism of Triglyceride-Rich Lipoproteins

Jan Borén et al.
Free Books & Documents

Excerpt

Triglycerides are critical lipids as they provide an energy source that is both compact and efficient. Due to its hydrophobic nature triglyceride molecules can pack together densely and so be stored in adipose tissue. To be transported in the aqueous medium of plasma, triglycerides have to be incorporated into lipoprotein particles along with other components such as cholesterol, phospholipid and associated structural and regulatory apolipoproteins. Here we discuss the physiology of normal triglyceride metabolism, and how impaired metabolism induces hypertriglyceridemia and its pathogenic consequences including atherosclerosis. We also discuss established and novel therapies to reduce triglyceride-rich lipoproteins.

PubMed Disclaimer

References

    1. Abdelhamid AS, Brown TJ, Brainard JS, Biswas P, Thorpe GC, Moore HJ, Deane KH, Summerbell CD, Worthington HV, Song F, Hooper L (2020) Omega-3 fatty acids for the primary and secondary prevention of cardiovascular disease. Cochrane Database Syst Rev 3:CD003177 - PMC - PubMed
    1. Adiels M, Packard C, Caslake MJ, Stewart P, Soro A, Westerbacka J, Wennberg B, Olofsson SO, Taskinen MR, Boren J (2005) A new combined multicompartmental model for apolipoprotein B-100 and triglyceride metabolism in VLDL subfractions. J Lipid Res 46(1):58–67 - PubMed
    1. Adiels M, Olofsson SO, Taskinen MR, Boren J (2006a) Diabetic dyslipidaemia. Curr Opin Lipidol 17(3):238–246 - PubMed
    1. Adiels M, Taskinen MR, Packard C, Caslake MJ, Soro-Paavonen A, Westerbacka J, Vehkavaara S, Hakkinen A, Olofsson SO, Yki-Jarvinen H, Boren J (2006b) Overproduction of large VLDL particles is driven by increased liver fat content in man. Diabetologia 49(4):755–765 - PubMed
    1. Adiels M, Matikainen N, Westerbacka J, Soderlund S, Larsson T, Olofsson SO, Boren J, Taskinen MR (2012) Postprandial accumulation of chylomicrons and chylomicron remnants is determined by the clearance capacity. Atherosclerosis 222(1):222–228 - PubMed

LinkOut - more resources