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Review

Neutrophil Extracellular Traps in Atherosclerosis and Thrombosis

Thomas M. Hofbauer  1 , Anna S. Ondracek  1 , Irene M. Lang  1
Arnold von Eckardstein  1 , Christoph J. Binder  2
, editors.
In: Prevention and Treatment of Atherosclerosis: Improving State-of-the-Art Management and Search for Novel Targets [Internet]. Cham (CH): Springer; 2022.
.
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Review

Neutrophil Extracellular Traps in Atherosclerosis and Thrombosis

Thomas M. Hofbauer et al.
Free Books & Documents

Excerpt

Despite effective therapeutic and preventive strategies, atherosclerosis and its complications still represent a substantial health burden. Leukocytes and inflammatory mechanisms are increasingly recognized as drivers of atherosclerosis. Neutrophil granulocytes within the circulation were recently shown to undergo neutrophil extracellular trap (NET) formation, linking innate immunity with acute complications of atherosclerosis. In this chapter, we summarize mechanisms of NET formation, evidence for their involvement in atherosclerosis and thrombosis, and potential therapeutic regimens specifically targeting NET components.

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