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. 2022 Sep 19;194(36):E1243-E1247.
doi: 10.1503/cmaj.220491.

Severe thrombotic complications secondary to antiphospholipid syndrome and undiagnosed systemic lupus erythematosus

Megan R W Barber  1 , Ann E Clarke  2 , Corey D Adams  2 , Leslie Skeith  2
Affiliations

Severe thrombotic complications secondary to antiphospholipid syndrome and undiagnosed systemic lupus erythematosus

Megan R W Barber et al. CMAJ. .
No abstract available

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Conflict of interest statement

Competing interests: Megan Barber is a coinvestigator of Antiphospholipid Syndrome Alliance for Clinical Trials and InternatiOnal Networking (APS-ACTION) and has received moderator fees from GSK, as well as advisory board fees from Janssen, Sanofi-Genzyme, AstraZeneca and Abbvie. Ann Clarke is a member of APS-ACTION and reports honoraria from AstraZeneca, Bristol Myers Squibb and GSK, as well as research funding from GSK. Leslie Skeith is a member of APS-ACTION and the Canadian Venous Thromboembolism Research Network (CanVECTOR), and reports honoraria from Leo Pharma and Sanofi. No other competing interests were declared.

Figures

Figure 1:
Figure 1:
Coronal computed tomography angiogram, maximum intensity projection, of a 22-year-old man with systemic lupus erythematosus and secondary antiphospholipid syndrome, showing complete occlusion of the infrarenal abdominal aorta and common iliac arteries, with reconstitution of bilateral femoral arterial perfusion via numerous collaterals, including the inferior epigastric, intercostal, superior mesenteric and inferior mesenteric artery branches. Blue arrows indicate inferior epigastric artery collaterals, purple arrow indicates superior rectal artery collaterals, green arrows indicate deep circumflex arteries (with collateralization via intercostal arteries, not shown) and white arrows indicate reconstituted flow in the femoral arteries via proximal collaterals.
Figure 2:
Figure 2:
Preoperative left and right coronary artery angiograms from a 22-year-old man with systemic lupus erythematosus and secondary antiphospholipid syndrome, showing diffuse disease throughout the coronary arteries. Arrows indicate a 50% stenosis of the left main (LM) artery, 100% occlusion of the proximal left anterior descending (pLAD) artery, 90% stenosis of the proximal left circumflex artery (pLCx) lesion, 40%–50% stenosis of the proximal and mid right coronary artery (pRCA and mRCA, respectively) and stenosis in the large dual ramus (RI) (60% in the more anterior branch and 80% in the posterior branch). The areas of stenosis were confirmed on multiplanar imaging.
See this image and copyright information in PMC

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