Comment on: What genes are differentially expressed in individuals with schizophrenia? A systematic review

Gabriel E Hoffman¹, Andrew E Jaffe^{2

3

4

5}, Michael J Gandal⁶, Leonardo Collado-Torres⁷, Solveig K Sieberts⁸, Bernie Devlin⁹, Daniel H Geschwind^{10

11}, Daniel R Weinberger^{12

13

7

14}, Panos Roussos^{15

16

17}

Affiliations

¹ Center for Disease Neurogenomics, Department of Psychiatry, Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA. gabriel.hoffman@mssm.edu.
² Department of Mental Health, Department of Biostatistics, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA. andrew.jaffe@neumoratx.com.
³ Department of Psychiatry and Behavioral Sciences, Department of Genetic Medicine, Department of Neuroscience, Johns Hopkins School of Medicine, Baltimore, MD, USA. andrew.jaffe@neumoratx.com.
⁴ Lieber Institute for Brain Development, Baltimore, MD, USA. andrew.jaffe@neumoratx.com.
⁵ Neumora Therapeutics, Watertown, MA, USA. andrew.jaffe@neumoratx.com.
⁶ Intellectual and Developmental Disabilities Research Center, Department of Psychiatry, Department of Human Genetics, Semel Institute for Neuroscience and Human Behavior, David Geffen School of Medicine, UCLA, Los Angeles, CA, USA. MGandal@mednet.ucla.edu.
⁷ Lieber Institute for Brain Development, Baltimore, MD, USA.
⁸ Sage Bionetworks, Seattle, Washington, USA.
⁹ Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
¹⁰ Intellectual and Developmental Disabilities Research Center, Department of Psychiatry, Department of Human Genetics, Semel Institute for Neuroscience and Human Behavior, David Geffen School of Medicine, UCLA, Los Angeles, CA, USA.
¹¹ Program in Neurogenetics, Department of Neurology, Center for Autism Research and Treatment, David Geffen School of Medicine, UCLA, Los Angeles, CA, USA.
¹² Department of Mental Health, Department of Biostatistics, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
¹³ Department of Psychiatry and Behavioral Sciences, Department of Genetic Medicine, Department of Neuroscience, Johns Hopkins School of Medicine, Baltimore, MD, USA.
¹⁴ Department of Neurology, Johns Hopkins School of Medicine, Baltimore, MD, USA.
¹⁵ Center for Disease Neurogenomics, Department of Psychiatry, Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
¹⁶ Mental Illness Research, Education and Clinical Centers, James J. Peters VA Medical Center, Bronx, NY, USA.
¹⁷ Center for Dementia Research, Nathan Kline Institute for Psychiatric Research, Orangeburg, NY, USA.

PMID: 36123423
PMCID: PMC10035364
DOI: 10.1038/s41380-022-01781-7

Comment

Comment on: What genes are differentially expressed in individuals with schizophrenia? A systematic review

Gabriel E Hoffman et al. Mol Psychiatry. 2023 Feb.

. 2023 Feb;28(2):523-525.

doi: 10.1038/s41380-022-01781-7. Epub 2022 Sep 19.

Authors

Affiliations

¹ Center for Disease Neurogenomics, Department of Psychiatry, Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA. gabriel.hoffman@mssm.edu.
² Department of Mental Health, Department of Biostatistics, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA. andrew.jaffe@neumoratx.com.
³ Department of Psychiatry and Behavioral Sciences, Department of Genetic Medicine, Department of Neuroscience, Johns Hopkins School of Medicine, Baltimore, MD, USA. andrew.jaffe@neumoratx.com.
⁴ Lieber Institute for Brain Development, Baltimore, MD, USA. andrew.jaffe@neumoratx.com.
⁵ Neumora Therapeutics, Watertown, MA, USA. andrew.jaffe@neumoratx.com.
⁶ Intellectual and Developmental Disabilities Research Center, Department of Psychiatry, Department of Human Genetics, Semel Institute for Neuroscience and Human Behavior, David Geffen School of Medicine, UCLA, Los Angeles, CA, USA. MGandal@mednet.ucla.edu.
⁷ Lieber Institute for Brain Development, Baltimore, MD, USA.
⁸ Sage Bionetworks, Seattle, Washington, USA.
⁹ Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
¹⁰ Intellectual and Developmental Disabilities Research Center, Department of Psychiatry, Department of Human Genetics, Semel Institute for Neuroscience and Human Behavior, David Geffen School of Medicine, UCLA, Los Angeles, CA, USA.
¹¹ Program in Neurogenetics, Department of Neurology, Center for Autism Research and Treatment, David Geffen School of Medicine, UCLA, Los Angeles, CA, USA.
¹² Department of Mental Health, Department of Biostatistics, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
¹³ Department of Psychiatry and Behavioral Sciences, Department of Genetic Medicine, Department of Neuroscience, Johns Hopkins School of Medicine, Baltimore, MD, USA.
¹⁴ Department of Neurology, Johns Hopkins School of Medicine, Baltimore, MD, USA.
¹⁵ Center for Disease Neurogenomics, Department of Psychiatry, Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
¹⁶ Mental Illness Research, Education and Clinical Centers, James J. Peters VA Medical Center, Bronx, NY, USA.
¹⁷ Center for Dementia Research, Nathan Kline Institute for Psychiatric Research, Orangeburg, NY, USA.

PMID: 36123423
PMCID: PMC10035364
DOI: 10.1038/s41380-022-01781-7

No abstract available

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Comment in

Reply to "Comment on: What genes are differentially expressed in individuals with schizophrenia? A systematic review".
Merikangas AK, Almasy L. Merikangas AK, et al. Mol Psychiatry. 2023 Feb;28(2):526-527. doi: 10.1038/s41380-022-01821-2. Epub 2022 Oct 12. Mol Psychiatry. 2023. PMID: 36224256 No abstract available.

Comment on

What genes are differentially expressed in individuals with schizophrenia? A systematic review.
Merikangas AK, Shelly M, Knighton A, Kotler N, Tanenbaum N, Almasy L. Merikangas AK, et al. Mol Psychiatry. 2022 Mar;27(3):1373-1383. doi: 10.1038/s41380-021-01420-7. Epub 2022 Jan 28. Mol Psychiatry. 2022. PMID: 35091668 Free PMC article.

References

1. Merikangas AK, Shelly M, Knighton A, Kotler N, Tanenbaum N, Almasy L. What genes are differentially expressed in individuals with schizophrenia? A systematic review. Mol Psychiatry 2022. doi: 10.1038/s41380-021-01420-7. - DOI - PMC - PubMed
1. Collado-Torres L, Burke EE, Peterson A, Shin J, Straub RE, Rajpurohit A et al. Regional Heterogeneity in Gene Expression, Regulation, and Coherence in the Frontal Cortex and Hippocampus across Development and Schizophrenia. Neuron 2019; 103: 203–216.e8. - PMC - PubMed
1. Jaffe AE, Straub RE, Shin JH, Tao R, Gao Y, Collado-Torres L et al. Developmental and genetic regulation of the human cortex transcriptome illuminate schizophrenia pathogenesis. Nat Neurosci 2018; 21: 1117–1125. - PMC - PubMed
1. Gandal MJ, Zhang P, Hadjimichael E, Walker RL, Chen C, Liu S et al. Transcriptome-wide isoform-level dysregulation in ASD, schizophrenia, and bipolar disorder. Science 2018; 362. doi: 10.1126/science.aat8127. - DOI - PMC - PubMed
1. Gandal MJ, Haney JR, Parikshak NN, Leppa V, Ramaswami G, Hartl C et al. Shared molecular neuropathology across major psychiatric disorders parallels polygenic overlap. Science 2018; 359: 693–697.

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Comment on: What genes are differentially expressed in individuals with schizophrenia? A systematic review

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