Implementing precision medicine in a regionally organized healthcare system in Sweden

Thoas Fioretos^{1

2

3}, Valtteri Wirta^{4

5

6}, Lucia Cavelier^{7

8

9}, Eva Berglund⁷, Mikaela Friedman⁸, Michael Akhras⁴, Johan Botling⁷, Hans Ehrencrona^{10

11}, Lars Engstrand¹², Gisela Helenius¹³, Therese Fagerqvist¹⁴, David Gisselsson^{10

11}, Sofia Gruvberger-Saal¹¹, Ulf Gyllensten⁷, Markus Heidenblad¹⁵, Kina Höglund¹⁶, Bo Jacobsson^{17

18}, Maria Johansson¹⁹, Åsa Johansson²⁰, Maria Johansson Soller^{5

8

9}, Maréne Landström²¹, Pär Larsson^{21

22}, Lars-Åke Levin²³, Anna Lindstrand^{5

8

9}, Lovisa Lovmar¹⁶, Anna Lyander^{4

6}, Malin Melin⁷, Ann Nordgren^{8

9

16

24}, Gunnel Nordmark²⁵, Paula Mölling²⁶, Lars Palmqvist^{24

27

28}, Richard Palmqvist²¹, Dirk Repsilber²⁹, Per Sikora^{16

27

30}, Bianca Stenmark²⁶, Peter Söderkvist^{31

32}, Henrik Stranneheim^{4

5

8}, Tobias Strid^{32

33}, Craig E Wheelock^{34

35}, Mia Wadelius³⁶, Anna Wedell^{5

8

37}, Anders Edsjö^{11

38}, Richard Rosenquist^{39

40

41}

Affiliations

¹ Division of Clinical Genetics, Department of Laboratory Medicine, Lund University, Lund, Sweden. thoas.fioretos@med.lu.se.
² Department of Clinical Genetics, Pathology and Molecular Diagnostics, Office for Medical Services, Region Skåne, Lund, Sweden. thoas.fioretos@med.lu.se.
³ Clinical Genomics Lund, Science for Life Laboratory, Lund University, Lund, Sweden. thoas.fioretos@med.lu.se.
⁴ Department of Microbiology, Tumor and Cell Biology, Clinical Genomics Stockholm, Science Life Laboratory, Karolinska Institutet, Solna, Sweden.
⁵ Genomic Medicine Center Karolinska, Karolinska University Hospital, Stockholm, Sweden.
⁶ School of Engineering Sciences in Chemistry, Biotechnology and Health, Clinical Genomics Stockholm, Science Life Laboratory, KTH Royal Institute of Technology, Stockholm, Sweden.
⁷ Department of Immunology, Genetics and Pathology, Clinical Genomics Uppsala, Science for Life Laboratory, Uppsala University, Uppsala, Sweden.
⁸ Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden.
⁹ Clinical Genetics, Karolinska University Hospital, Solna, Sweden.
¹⁰ Division of Clinical Genetics, Department of Laboratory Medicine, Lund University, Lund, Sweden.
¹¹ Department of Clinical Genetics, Pathology and Molecular Diagnostics, Office for Medical Services, Region Skåne, Lund, Sweden.
¹² Department of Microbiology, Tumor and Cell Biology, Centre for Translational Microbiome Research, Karolinska Institutet, Solna, Sweden.
¹³ Department of Laboratory Medicine, Faculty of Medicine and Health, Örebro University, Örebro, Sweden.
¹⁴ Innovation Partnership Office, Uppsala University, Uppsala, Sweden.
¹⁵ Clinical Genomics Lund, Science for Life Laboratory, Lund University, Lund, Sweden.
¹⁶ Department of Clinical Genetics and Genomics, Sahlgrenska University Hospital, Gothenburg, Sweden.
¹⁷ Department of Obstetrics and Gynecology, Sahlgrenska Academy, Gothenburg University, Gothenburg, Sweden.
¹⁸ Department of Obstetrics and Gynecology, Sahlgrenska University Hospital, Gothenburg, Sweden.
¹⁹ Lund University Collaboration Office, Lund University, Lund, Sweden.
²⁰ Department of Immunology, Genetics and Pathology, Science for Life Laboratory, Uppsala University, Uppsala, Sweden.
²¹ Department of Medical Biosciences, Umeå University, Umeå, Sweden.
²² Clinical Genomics Umeå, Science for Life Laboratory, Umeå University, Umeå, Sweden.
²³ Department of Health, Medicine and Caring Sciences, Linköping University, Linköping, Sweden.
²⁴ Institute of Biomedicine, Department of Laboratory Medicine, University of Gothenburg, Gothenburg, Sweden.
²⁵ Department of Medical Sciences, Rheumatology, Uppsala University, Uppsala, Sweden.
²⁶ Department of Laboratory Medicine, Clinical Pathology and Genetics, Faculty of Medicine and Health, Örebro University, Örebro, Sweden.
²⁷ Clinical Genomics Gothenburg, Science for Life Laboratory, University of Gothenburg, Gothenburg, Sweden.
²⁸ Department of Clinical Chemistry, Sahlgrenska University Hospital, Gothenburg, Sweden.
²⁹ School of Medical Sciences, Örebro University, Örebro, Sweden.
³⁰ Bioinformatics Data Center, Core Facilities, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
³¹ Division of Medical Genetics, Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden.
³² Clinical Genomics Linköping, Linköping University, Linköping, Sweden.
³³ Department of Clinical Pathology, Biological and Clinical Sciences, Linköping University, Linköping, Sweden.
³⁴ Unit of Integrative Metabolomics, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
³⁵ Department of Respiratory Medicine and Allergy, Karolinska University Hospital, Stockholm, Sweden.
³⁶ Department of Medical Sciences, Clinical Pharmacogenomics, Science for Life Laboratory, Uppsala University, Uppsala, Sweden.
³⁷ Centre for Inherited Metabolic Diseases, Karolinska University Hospital, Stockholm, Sweden.
³⁸ Division of Pathology, Department of Clinical Sciences, Lund University, Lund, Sweden.
³⁹ Genomic Medicine Center Karolinska, Karolinska University Hospital, Stockholm, Sweden. richard.rosenquist@ki.se.
⁴⁰ Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden. richard.rosenquist@ki.se.
⁴¹ Clinical Genetics, Karolinska University Hospital, Solna, Sweden. richard.rosenquist@ki.se.

PMID: 36123428
DOI: 10.1038/s41591-022-01963-4

Implementing precision medicine in a regionally organized healthcare system in Sweden

Thoas Fioretos et al. Nat Med. 2022 Oct.

. 2022 Oct;28(10):1980-1982.

doi: 10.1038/s41591-022-01963-4.

Authors

Affiliations

¹ Division of Clinical Genetics, Department of Laboratory Medicine, Lund University, Lund, Sweden. thoas.fioretos@med.lu.se.
² Department of Clinical Genetics, Pathology and Molecular Diagnostics, Office for Medical Services, Region Skåne, Lund, Sweden. thoas.fioretos@med.lu.se.
³ Clinical Genomics Lund, Science for Life Laboratory, Lund University, Lund, Sweden. thoas.fioretos@med.lu.se.
⁴ Department of Microbiology, Tumor and Cell Biology, Clinical Genomics Stockholm, Science Life Laboratory, Karolinska Institutet, Solna, Sweden.
⁵ Genomic Medicine Center Karolinska, Karolinska University Hospital, Stockholm, Sweden.
⁶ School of Engineering Sciences in Chemistry, Biotechnology and Health, Clinical Genomics Stockholm, Science Life Laboratory, KTH Royal Institute of Technology, Stockholm, Sweden.
⁷ Department of Immunology, Genetics and Pathology, Clinical Genomics Uppsala, Science for Life Laboratory, Uppsala University, Uppsala, Sweden.
⁸ Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden.
⁹ Clinical Genetics, Karolinska University Hospital, Solna, Sweden.
¹⁰ Division of Clinical Genetics, Department of Laboratory Medicine, Lund University, Lund, Sweden.
¹¹ Department of Clinical Genetics, Pathology and Molecular Diagnostics, Office for Medical Services, Region Skåne, Lund, Sweden.
¹² Department of Microbiology, Tumor and Cell Biology, Centre for Translational Microbiome Research, Karolinska Institutet, Solna, Sweden.
¹³ Department of Laboratory Medicine, Faculty of Medicine and Health, Örebro University, Örebro, Sweden.
¹⁴ Innovation Partnership Office, Uppsala University, Uppsala, Sweden.
¹⁵ Clinical Genomics Lund, Science for Life Laboratory, Lund University, Lund, Sweden.
¹⁶ Department of Clinical Genetics and Genomics, Sahlgrenska University Hospital, Gothenburg, Sweden.
¹⁷ Department of Obstetrics and Gynecology, Sahlgrenska Academy, Gothenburg University, Gothenburg, Sweden.
¹⁸ Department of Obstetrics and Gynecology, Sahlgrenska University Hospital, Gothenburg, Sweden.
¹⁹ Lund University Collaboration Office, Lund University, Lund, Sweden.
²⁰ Department of Immunology, Genetics and Pathology, Science for Life Laboratory, Uppsala University, Uppsala, Sweden.
²¹ Department of Medical Biosciences, Umeå University, Umeå, Sweden.
²² Clinical Genomics Umeå, Science for Life Laboratory, Umeå University, Umeå, Sweden.
²³ Department of Health, Medicine and Caring Sciences, Linköping University, Linköping, Sweden.
²⁴ Institute of Biomedicine, Department of Laboratory Medicine, University of Gothenburg, Gothenburg, Sweden.
²⁵ Department of Medical Sciences, Rheumatology, Uppsala University, Uppsala, Sweden.
²⁶ Department of Laboratory Medicine, Clinical Pathology and Genetics, Faculty of Medicine and Health, Örebro University, Örebro, Sweden.
²⁷ Clinical Genomics Gothenburg, Science for Life Laboratory, University of Gothenburg, Gothenburg, Sweden.
²⁸ Department of Clinical Chemistry, Sahlgrenska University Hospital, Gothenburg, Sweden.
²⁹ School of Medical Sciences, Örebro University, Örebro, Sweden.
³⁰ Bioinformatics Data Center, Core Facilities, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
³¹ Division of Medical Genetics, Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden.
³² Clinical Genomics Linköping, Linköping University, Linköping, Sweden.
³³ Department of Clinical Pathology, Biological and Clinical Sciences, Linköping University, Linköping, Sweden.
³⁴ Unit of Integrative Metabolomics, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
³⁵ Department of Respiratory Medicine and Allergy, Karolinska University Hospital, Stockholm, Sweden.
³⁶ Department of Medical Sciences, Clinical Pharmacogenomics, Science for Life Laboratory, Uppsala University, Uppsala, Sweden.
³⁷ Centre for Inherited Metabolic Diseases, Karolinska University Hospital, Stockholm, Sweden.
³⁸ Division of Pathology, Department of Clinical Sciences, Lund University, Lund, Sweden.
³⁹ Genomic Medicine Center Karolinska, Karolinska University Hospital, Stockholm, Sweden. richard.rosenquist@ki.se.
⁴⁰ Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden. richard.rosenquist@ki.se.
⁴¹ Clinical Genetics, Karolinska University Hospital, Solna, Sweden. richard.rosenquist@ki.se.

PMID: 36123428
DOI: 10.1038/s41591-022-01963-4

No abstract available

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References

1. Investigators, G. P. P. et al. N. Engl. J. Med 385, 1868–1880 (2021). - DOI
1. Levy, Y. Lancet 388, 2872 (2016). - DOI
1. Stenzinger, A. et al. Semin. Cancer Biol. 4, 242–254 (2022). - DOI
1. Lindstrand, A. et al. Genome Med. 11, 68 (2019). - DOI
1. Stranneheim, H. et al. BMC Genomics 15, 1090 (2014). - DOI

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Implementing precision medicine in a regionally organized healthcare system in Sweden

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Implementing precision medicine in a regionally organized healthcare system in Sweden

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