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. 2022 Sep 10:2022:4259499.
doi: 10.1155/2022/4259499. eCollection 2022.

Epidural Anesthesia versus General Anesthesia for Total Knee Arthroplasty: Influences on Perioperative Cognitive Function and Deep Vein Thrombosis

Tao Ma  1 , Guanhua Li  1 , Hao Zhang  1 , Yingxin Zhang  1 , Lei Wang  1 , Hailong Wu  1 , Yang Chu  1 , Xiaoli Zhao  1 , Wei Wang  1
Affiliations

Epidural Anesthesia versus General Anesthesia for Total Knee Arthroplasty: Influences on Perioperative Cognitive Function and Deep Vein Thrombosis

Tao Ma et al. Comput Math Methods Med. .

Retraction in

Abstract

Purpose: This research mainly discussed the impacts of epidural anesthesia (EA) and general anesthesia (GA) on perioperative cognitive function (CF) and deep vein thrombosis (DVT) in patients undergoing total knee arthroplasty (TKA).

Methods: One hundred and twenty-four patients undergoing TKA in our hospital between July 2015 and October 2021 were selected, of which 74 patients received EA (research group) and the other 50 patients received GA (control group). Perioperative CF, DVT, stress response indicators (norepinephrine, NE; cortisol, Cor), and heart rate (HR) levels were observed and compared. Risk factors affecting DVT of TKA patients were analyzed by logistic regression.

Results: The research group had statistically better CF than the control group, with notably lower NE, Cor, and HR levels and incidence of DVT. Logistic regression analysis showed that the type of anesthesia and MoCA were risk factors for DVT in TKA patients.

Conclusion: EA is more feasible for patients undergoing TKA, which is conducive to improving their CF, relieving stress responses, and reducing the incidence of DVT, with a certain sedative effect.

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Conflict of interest statement

The authors declare no competing interests.

Figures

Figure 1
Figure 1
Cognitive function of TKA patients. ∗∗P < 0.01. Paired t-test was used to analyze the measurement data between groups before and after the intervention.
Figure 2
Figure 2
Stress response and HR level of TKA patients. (a) The HR level of TKA patients in both groups increased significantly at T2 and T3, and the HR level in the research group was lower than that in the control group at T4. (b) The NE level of TKA patients in both groups increased significantly at T4, with a lower level in the research group. (c) The Cor level of TKA patients in both groups increased significantly at T4, with a lower level in the research group. Note: ∗∗P < 0.01. Paired t-test was used to analyze the measurement data between groups before and after the intervention.
Figure 3
Figure 3
DVT in TKA patients. Chi-square test was used to analyze the incidence of DVT in both groups.
See this image and copyright information in PMC

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