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. 1987 Apr;15(2):145-77.
doi: 10.1007/BF01062341.

Multicompartment models of cancer chemotherapy incorporating resistant cell populations

H N Duc, P M Nickolls

Multicompartment models of cancer chemotherapy incorporating resistant cell populations

H N Duc et al. J Pharmacokinet Biopharm. 1987 Apr.

Abstract

The pharmacokinetics of antineoplastic drugs based on compartmental models are combined with deterministic exponential growth models of tumors containing drug-resistant and sensitive cells. Model predictions for single-drug therapy are compared with in vivo data obtained by other investigators for L1210 t-cell leukemia in mice treated with BCNU and Ara-C and for in vitro treatment of L1210 with Ara-C. The model and data compare favorably in terms of rate of tumor growth and duration of drug action for both constant infusion and bolus delivery of the drugs.

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