Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2022 Oct;48(5):1365-1375.
doi: 10.1007/s10695-022-01125-w. Epub 2022 Sep 20.

Effects of long-term sex steroid hormones (estradiol and testosterone)-supplemented feeds on the growth performance of Chinese tongue sole (Cynoglossus semilaevis)

Mengqian Zhang #  1 , Qian Yang #  1   2 , Rui Shi  1   2 , Jialin Wang  1   2 , Ziwei Zhang  1   3 , Yingming Yang  1   3   4 , Wenlong Li  1   3   4 , Songlin Chen  1   3   4 , Na Wang  5   6   7
Affiliations

Effects of long-term sex steroid hormones (estradiol and testosterone)-supplemented feeds on the growth performance of Chinese tongue sole (Cynoglossus semilaevis)

Mengqian Zhang et al. Fish Physiol Biochem. 2022 Oct.

Abstract

The phenomenon of sexual size dimorphism (SSD), existing in mammals, birds, reptiles, spiders, amphibians, insects, and fishes, is generally related to feeding efficiency, energy allocation, sex steroids, and somatotropic and reproductive endocrine axes. Recently, positive and negative regulations of sex steroids have been reported on SSD in various species. Chinese tongue soles (Cynoglossus semilaevis) at 4 months were fed with 17β-estradiol (E2) and testosterone (T) supplemented feeds for 8 months to assess the effect of sex steroids on growth traits in different sexes. The potential genetic regulation was examined using several growth-related genes. The results showed that two sex steroid hormones had inhibitory effects on the growth performance of different sexes of C. semilaevis. At the age of 8 months, the expression of insulin-like growth factor 2 gene (igf2), 24-dehydrocholesterol reductase (dhcr24), leptin, and estrogen receptor 2 (esr2) in the liver showed an overall downward trend. The expression of insulin-like growth factor 1 (igf1) was reduced, while thyroid hormone receptor-associated protein 3 (thrap3) expression tended to increase in the gonad after T and E2 treatments. In the brain, somatostatin 1, tandem duplicate 2 (sst1.2) expression increased with the treatment of T and E2 (P < 0.05), while growth hormone-releasing hormone (ghrh) expression decreased. E2 and T had different effects on growth differentiation factor 8 (gdf8) and insulin-like growth factor-binding protein 7 (igfbp7) expression in the muscle. Expression of gdf8 increased in the treated fishes in contrast to the reduction expression of igfbp7. This study provided important clues for understanding the role of sex steroids in flatfish SSD.

Keywords: Chinese tongue sole (Cynoglossus semilaevis); Estradiol; Sexual size dimorphism (SSD); Testosterone.

PubMed Disclaimer

References

    1. Boulle N, Baudin E, Gicquel C, Logie A, Bertherat J, Penfornis A, Bertagna X, Luton J-P, Schlumberger M, Le Bouc Y (2001) Evaluation of plasma insulin-like growth factor binding protein-2 as a marker for adrenocortical tumors. Eur J Endocrinol 144:29–36. https://doi.org/10.1530/eje.0.1440029 - DOI - PubMed
    1. Brent GA (2012) Mechanisms of thyroid hormone action. J Clin Invest 122(9):3035–3043. https://doi.org/10.1172/JCI60047 - DOI - PubMed - PMC
    1. Chen SL, Zhang GJ, Shao CW, Huang QF, Liu G, Zhang P, Song WT, An N, Chalopin D, Volff JN, Hong YH, Li QY, Sha ZX, Zhou HL, Xie MS, Yu QL, Liu Y, Xiang H, Wang N, Wu K, Yang CG, Zhou Q, Liao XL, Yang LF, Hu QM, Zhang JL, Meng L, Jin LJ, Tian YS, Lian JM, Yang JF, Miao GD, Liu SS, Liang Z, Yan F, Li YZ, Sun B, Zhang H, Zhang J, Zhu Y, Du M, Zhao YW, Schartl M, Tang QS, Wang J (2014) Whole-genome sequence of a flatfish provides insights into ZW sex chromosome evolution and adaptation to a benthic lifestyle. Nat Genet 46:253–260. https://doi.org/10.1038/ng.2890 - DOI - PubMed
    1. Cleveland BM, Weber GM (2016) Effects of steroid treatment on growth, nutrient partitioning, and expression of genes related to growth and nutrient metabolism in adult triploid rainbow trout (Oncorhynchus mykiss). Domest Anim Endocrinol 56:1–12. https://doi.org/10.1016/j.domaniend.2016.01.001 - DOI - PubMed
    1. Cox RM, John-Alder HB (2005) Testosterone has opposite effects on male growth in lizards (Sceloporus spp.) with opposite patterns of sexual size dimorphism. J Exp Biol 208:4679–4687. https://doi.org/10.1242/jeb.01948 - DOI - PubMed

LinkOut - more resources