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Comment
. 2022 Oct 1;71(10):2075-2077.
doi: 10.2337/dbi22-0012.

A Reassessment of the Causal Effects of Dysglycemia on Atherosclerotic and Thrombotic Events

Jordi Merino  1   2   3
Affiliations
Comment

A Reassessment of the Causal Effects of Dysglycemia on Atherosclerotic and Thrombotic Events

Jordi Merino. Diabetes. .
No abstract available

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Figures

Figure 1
Figure 1
Overview of the study and findings. In a two-sample Mendelian randomization study using summary statistics for four glycemic traits, including fasting glucose, fasting insulin, 2-h glucose, and HbA1c from MAGIC, and outcome data for 12 atherosclerotic outcomes (coronary artery disease, angina, coronary atherosclerosis, coronary revascularization, ischemic stroke, and its three subtypes, transient ischemic attack, aortic aneurysm, peripheral artery disease, and chronic kidney disease) and 4 thrombotic outcomes (subarachnoid hemorrhage, venous thromboembolism, and its two subtypes, deep vein thrombosis and pulmonary embolism) from the UK Biobank and FinnGen studies and large-scale genetic consortia, results provide evidence that hyperglycemia, hyperinsulinemia, and impaired glucose tolerance are causally associated with a wide range of atherosclerotic events but not thrombotic events. These findings provide a unique perspective on the impact of hyperglycemia on the development of atherosclerosis and cardiovascular complications among people with prediabetes and diabetes. Displayed outcomes with Benjamini-Hochberg–adjusted P value <0.05. Outcomes positively associated with dysglycemia are represented in red, while outcomes inversely associated with dysglycemia are denoted in green. Figure created with BioRender (https://biorender.com/).
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