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Review
. 2022 Nov 1:308:120974.
doi: 10.1016/j.lfs.2022.120974. Epub 2022 Sep 17.

Functional roles of lncRNA-TUG1 in hepatocellular carcinoma

Maryam Farzaneh  1 , Majid Ghasemian  2 , Farhoodeh Ghaedrahmati  3 , Jafar Poodineh  4 , Sajad Najafi  5 , Tariq Masoodi  6 , Dedy Kurniawan  7 , Shahab Uddin  8 , Shirin Azizidoost  9
Affiliations
Review

Functional roles of lncRNA-TUG1 in hepatocellular carcinoma

Maryam Farzaneh et al. Life Sci. .

Abstract

Hepatocellular carcinoma (HCC) or hepatoma is malignant cancer that starts from the main liver cells. Although various classical methods have been used for patients with HCC, various molecular mechanisms involved in HCC progression should be invested. Previous studies demonstrated that abnormal expression of long non-coding RNAs (lncRNAs) presented important roles in the pathogenesis of HCC cells. LncRNA TUG1 was found to mediate HCC cell growth, EMT, and metastasis. Therefore, targeting TUG1 and its downstream genes may be a suitable approach for patients with HCC. In this review, we summarized the potential roles of TUG1 in HCC.

Keywords: Hepatocellular carcinoma; LncRNAs; Pathogenesis; TUG1.

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Conflict of interest statement

Declaration of competing interest The authors declare no conflict of interest.

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