Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1987 Jun;24(6):362-5.
doi: 10.1136/jmg.24.6.362.

Inbreeding and the incidence of childhood genetic disorders in Karnataka, South India

A R Devi, N A Rao, A H Bittles

Inbreeding and the incidence of childhood genetic disorders in Karnataka, South India

A R Devi et al. J Med Genet. 1987 Jun.

Abstract

Consanguineous marriages are strongly favoured among the populations of South India. In a study conducted on 407 infants and children, a total of 35 genetic diseases was diagnosed in 63 persons: 44 with single gene defects, 12 with polygenic disorders, and seven with Down's syndrome. The coefficient of inbreeding of the total study group, F = 0.0414, was significantly higher than that previously calculated for the general population, F = 0.0271, and autosomal recessive disorders formed the largest single disease category diagnosed. The results suggest that long term inbreeding may not have resulted in appreciable elimination of recessive lethals and sub-lethals from the gene pool.

PubMed Disclaimer

References

    1. Br Med J. 1968 Jun 22;2(5607):745-9 - PubMed
    1. J Lab Clin Med. 1960 Jan;55:136-8 - PubMed
    1. Arch Dis Child. 1970 Feb;45(239):33-8 - PubMed
    1. Indian J Med Res. 1971 Feb;59(2):294-301 - PubMed
    1. Ann Hum Genet. 1977 Jul;41(1):87-98 - PubMed

Publication types