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Case Reports
. 1987 Jul;24(7):410-2.
doi: 10.1136/jmg.24.7.410.

Wolf-Hirschhorn locus is distal to D4S10 on short arm of chromosome 4

C McKeown, A P Read, A Dodge, O Stecko, A Mercer, R Harris
Case Reports

Wolf-Hirschhorn locus is distal to D4S10 on short arm of chromosome 4

C McKeown et al. J Med Genet. 1987 Jul.

Abstract

We report a family in which Wolf-Hirschhorn syndrome in two children with partial monosomy of the short arm of chromosome 4 is the result of unbalanced segregation of a reciprocal 4;12 translocation in the mother. Studies with the DNA probe G8 show that the translocation breakpoint in this family is distal to the D4S10 locus. Previously reported cases of Wolf-Hirschhorn syndrome have involved the deletion of D4S10. These observations may prove helpful in the search for better genetic markers for Huntington's chorea, which maps close to D4S10.

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References

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