IgM-secreting diffuse large B-cell lymphoma: results of a multicentre clinicopathological and molecular study

M Christina Cox¹, Luigi Marcheselli², Giorgia Scafetta³, Carlo Visco⁴, Stefan Hohaus⁵, Ombretta Annibali⁶, Gerardo Musuraca⁷, Alberto Fabbri⁸, Maria Cantonetti⁹, Sabrina Pelliccia³, Robel Papotti¹⁰, Luigi Petrucci¹¹, Monica Tani¹², Roberta Battistini¹³, Annalisa Arcari¹⁴, Stefano Luminari¹⁵, Gianluca Lopez³, Eleonora Alma⁵, Livio Pupo⁹, Giuseppe Carli¹⁶, Francesco Marchesi¹⁷, Francesca Re¹⁸, Stefania Scarpino³, Emanuele S G D'amore¹⁶, Luigi M Larocca⁵, Antonella Bianchi⁶, Giuseppina Pepe³, Fiammetta Natalino¹⁹, Paola Anticoli-Borza²⁰, Natalia Cenfra²¹, Alessandro Andriani²², Elisabetta Abruzzese²³, Cristiano Tesei⁹, Lorenzo Leoncini⁸, Silvia Asioli⁷, Luigi Ruco³, Arianna Di Napoli²⁴

Affiliations

¹ Fondazione Policlinico Tor Vergata, University Hospital, Rome, Italy. chrisscox@gmail.com.
² Fondazione Italiana Linfomi, Alessandria, Italy.
³ Department of Clinical and Molecular Medicine, Sapienza University, Sant'Andrea University Hospital, Rome, Italy.
⁴ University of Verona, Verona, Italy.
⁵ Università Cattolica del Sacro Cuore, Policlinico Agostino Gemelli, Roma, Italy.
⁶ Campus Biomedico, Rome, Italy.
⁷ Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori, Meldola, Italy.
⁸ Azienda Ospedaliera universitaria Senese, Siena, Italy.
⁹ Fondazione Policlinico Tor Vergata, University Hospital, Rome, Italy.
¹⁰ Chimomo department, university of Modena and Reggio Emilia, Modena, Italy.
¹¹ Policlinico Umberto I University Hospital, Rome, Italy.
¹² Ospedale Santa Maria delle Croci, Ravenna, Italy.
¹³ Azienda Ospedaliera San Camillo, Rome, Italy.
¹⁴ Azienda USL, Piacenza, Italy.
¹⁵ Hematology Ausl IRCCS of Reggio Emilia & Chimomo department, university of Modena and Reggio Emilia, Reggio Emilia, Italy.
¹⁶ Ospedale San Bortolo, Azienda USSL 8, Vicenza, Italy.
¹⁷ IRCCS Regina Elena National Cancer Institute, Rome, Italy.
¹⁸ Azienda Ospedaliera Universitaria, Parma, Italy.
¹⁹ Azienda Ospedaliera, Viterbo, Italy.
²⁰ Azienda Ospedaliera San Giovanni, Rome, Italy.
²¹ Azienda Ospedaliera Universitaria, Latina, Italy.
²² Azienda Ospedaliera, Frosinone, Italy.
²³ Azienda Ospedaliera Sant'Eugenio, Rome, Italy.
²⁴ Department of Clinical and Molecular Medicine, Sapienza University, Sant'Andrea University Hospital, Rome, Italy. arianna.dinapoli@uniroma1.it.

PMID: 36127510
DOI: 10.1038/s41375-022-01706-x

Multicenter Study

IgM-secreting diffuse large B-cell lymphoma: results of a multicentre clinicopathological and molecular study

M Christina Cox et al. Leukemia. 2022 Nov.

. 2022 Nov;36(11):2719-2723.

doi: 10.1038/s41375-022-01706-x. Epub 2022 Sep 20.

Authors

Affiliations

¹ Fondazione Policlinico Tor Vergata, University Hospital, Rome, Italy. chrisscox@gmail.com.
² Fondazione Italiana Linfomi, Alessandria, Italy.
³ Department of Clinical and Molecular Medicine, Sapienza University, Sant'Andrea University Hospital, Rome, Italy.
⁴ University of Verona, Verona, Italy.
⁵ Università Cattolica del Sacro Cuore, Policlinico Agostino Gemelli, Roma, Italy.
⁶ Campus Biomedico, Rome, Italy.
⁷ Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori, Meldola, Italy.
⁸ Azienda Ospedaliera universitaria Senese, Siena, Italy.
⁹ Fondazione Policlinico Tor Vergata, University Hospital, Rome, Italy.
¹⁰ Chimomo department, university of Modena and Reggio Emilia, Modena, Italy.
¹¹ Policlinico Umberto I University Hospital, Rome, Italy.
¹² Ospedale Santa Maria delle Croci, Ravenna, Italy.
¹³ Azienda Ospedaliera San Camillo, Rome, Italy.
¹⁴ Azienda USL, Piacenza, Italy.
¹⁵ Hematology Ausl IRCCS of Reggio Emilia & Chimomo department, university of Modena and Reggio Emilia, Reggio Emilia, Italy.
¹⁶ Ospedale San Bortolo, Azienda USSL 8, Vicenza, Italy.
¹⁷ IRCCS Regina Elena National Cancer Institute, Rome, Italy.
¹⁸ Azienda Ospedaliera Universitaria, Parma, Italy.
¹⁹ Azienda Ospedaliera, Viterbo, Italy.
²⁰ Azienda Ospedaliera San Giovanni, Rome, Italy.
²¹ Azienda Ospedaliera Universitaria, Latina, Italy.
²² Azienda Ospedaliera, Frosinone, Italy.
²³ Azienda Ospedaliera Sant'Eugenio, Rome, Italy.
²⁴ Department of Clinical and Molecular Medicine, Sapienza University, Sant'Andrea University Hospital, Rome, Italy. arianna.dinapoli@uniroma1.it.

PMID: 36127510
DOI: 10.1038/s41375-022-01706-x

No abstract available

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References

1. Cox MC, Di Napoli A, Scarpino S, Salerno G, Tatarelli C, Talerico C, et al. Clinicopathologic characterization of diffuse-large-B-cell lymphoma with an associated serum monoclonal IgM component. PLoS One. 2014;9:e93903. - DOI - PubMed - PMC
1. Wright G, Tan B, Rosenwald A, Hurt EH, Wiestner A, Staudt LM. A gene expression-based method to diagnose clinically distinct subgroups of diffuse large B cell lymphoma. Proc Natl Acad Sci USA. 2003;100:9991–6. - DOI - PubMed - PMC
1. Scharer CD, Patterson DG, Mi T, Price MJ, Hicks SL, Boss JM. Antibody-secreting cell destiny emerges during the initial stages of B-cell activation. Nat Commun. 2020;11:3989. - DOI - PubMed - PMC
1. Maurer MJ, Micallef IN, Cerhan JR, Katzmann JA, Link BK, Colgan JP, et al. Elevated serum free light chains are associated with event-free and overall survival in two independent cohorts of patients with diffuse large B-cell lymphoma. J Clin Oncol. 2011;29:1620–6. - DOI - PubMed - PMC
1. Jardin F, Delfau-Larue MH, Molina TJ, Copie-Bergman C, Brière J, Petrella T, et al. Immunoglobulin heavy chain/light chain pair measurement is associated with survival in diffuse large B-cell lymphoma. Leuk Lymphoma. 2013;54:1898–907. - DOI - PubMed

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IgM-secreting diffuse large B-cell lymphoma: results of a multicentre clinicopathological and molecular study

Affiliations

IgM-secreting diffuse large B-cell lymphoma: results of a multicentre clinicopathological and molecular study

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