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. 2022:2546:1-12.
doi: 10.1007/978-1-0716-2565-1_1.

Introduction to Mass Spectrometry for Bimolecular Analysis in a Clinical Laboratory

Y Victoria Zhang  1 , Uttam Garg  2
Affiliations

Introduction to Mass Spectrometry for Bimolecular Analysis in a Clinical Laboratory

Y Victoria Zhang et al. Methods Mol Biol. 2022.

Abstract

Mass spectrometry is a technique that identifies analytes based on mass-to-charge (m/z) ratio and structural fragments. Although this technique has been used in research and specialized clinical laboratories for decades, only in recent years has mass spectrometry become popular in routine clinical laboratories. Mass spectrometry, especially when coupled with gas chromatography or liquid chromatography, provides very specific and often sensitive analysis of many analytes. Other advantages of mass spectrometry include simultaneous analysis of multiple analytes (>100) and generally limited requirement for specialized reagents. Commonly measured analytes by mass spectrometry include metabolites, drugs, hormones, and proteins.

Keywords: Clinical laboratory; Endocrinology; Gas chromatography; Hormones and proteins; Liquid chromatography; Mass spectrometry; Newborn screening; Tandem mass spectrometry.

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