Passenger donor lymphocytes: To affinity and beyond

Affiliations

¹ Department of Surgery, University of Cambridge, Cambridge CB2 0QQ, UK.
² Department of Surgical Biotechnology and Institute of Immunity and Transplantation, University College London, London NW3 2PP, UK.

Comment

Miriam Manook et al. Sci Transl Med. 2022.

. 2022 Sep 21;14(663):eadd2145.

doi: 10.1126/scitranslmed.add2145. Epub 2022 Sep 21.

¹ Department of Surgery, University of Cambridge, Cambridge CB2 0QQ, UK.
² Department of Surgical Biotechnology and Institute of Immunity and Transplantation, University College London, London NW3 2PP, UK.

Abstract

Graft-versus-host recognition by passenger donor lymphocytes within organ transplants can trigger host alloantibody production (Charmetant et al.).

Inverted direct allorecognition triggers early donor-specific antibody responses after transplantation.
Charmetant X, Chen CC, Hamada S, Goncalves D, Saison C, Rabeyrin M, Rabant M, Duong van Huyen JP, Koenig A, Mathias V, Barba T, Lacaille F, le Pavec J, Brugière O, Taupin JL, Chalabreysse L, Mornex JF, Couzi L, Graff-Dubois S, Jeger-Madiot R, Tran-Dinh A, Mordant P, Paidassi H, Defrance T, Morelon E, Badet L, Nicoletti A, Dubois V, Thaunat O. Charmetant X, et al. Sci Transl Med. 2022 Sep 21;14(663):eabg1046. doi: 10.1126/scitranslmed.abg1046. Epub 2022 Sep 21. Sci Transl Med. 2022. PMID: 36130013