Sonogenetics: Recent advances and future directions

Tianyi Liu¹, Mi Hyun Choi², Jiejun Zhu¹, Tingting Zhu¹, Jin Yang¹, Na Li³, Zihao Chen³, Quanxiang Xian⁴, Xuandi Hou⁴, Dongmin He¹, Jinghui Guo⁵, Chunlong Fei⁶, Lei Sun⁷, Zhihai Qiu⁸

Affiliations

¹ Guangdong Institute of Intelligence Science and Technology, Hengqin, Zhuhai, Guangdong, 519031, China.
² Department of Bioengineering, Stanford University, CA, USA.
³ Guangdong Institute of Intelligence Science and Technology, Hengqin, Zhuhai, Guangdong, 519031, China; School of Microelectronics, Xidian University, Xi'an, China.
⁴ Department of Biomedical Engineering, The Hong Kong Polytechnic University, Hung Hom, Hong Kong SAR, China.
⁵ Department of Biomedical Engineering, The Hong Kong Polytechnic University, Hung Hom, Hong Kong SAR, China; Department of Physiology, Faculty of Medicine, Jinan University, Guangzhou, China.
⁶ School of Microelectronics, Xidian University, Xi'an, China.
⁷ Department of Biomedical Engineering, The Hong Kong Polytechnic University, Hung Hom, Hong Kong SAR, China. Electronic address: lei.sun@polyu.edu.hk.
⁸ Guangdong Institute of Intelligence Science and Technology, Hengqin, Zhuhai, Guangdong, 519031, China. Electronic address: qiuzhihai@gdiist.cn.

PMID: 36130679
DOI: 10.1016/j.brs.2022.09.002

Review

Sonogenetics: Recent advances and future directions

Tianyi Liu et al. Brain Stimul. 2022 Sep-Oct.

. 2022 Sep-Oct;15(5):1308-1317.

doi: 10.1016/j.brs.2022.09.002. Epub 2022 Sep 18.

Authors

Affiliations

¹ Guangdong Institute of Intelligence Science and Technology, Hengqin, Zhuhai, Guangdong, 519031, China.
² Department of Bioengineering, Stanford University, CA, USA.
³ Guangdong Institute of Intelligence Science and Technology, Hengqin, Zhuhai, Guangdong, 519031, China; School of Microelectronics, Xidian University, Xi'an, China.
⁴ Department of Biomedical Engineering, The Hong Kong Polytechnic University, Hung Hom, Hong Kong SAR, China.
⁵ Department of Biomedical Engineering, The Hong Kong Polytechnic University, Hung Hom, Hong Kong SAR, China; Department of Physiology, Faculty of Medicine, Jinan University, Guangzhou, China.
⁶ School of Microelectronics, Xidian University, Xi'an, China.
⁷ Department of Biomedical Engineering, The Hong Kong Polytechnic University, Hung Hom, Hong Kong SAR, China. Electronic address: lei.sun@polyu.edu.hk.
⁸ Guangdong Institute of Intelligence Science and Technology, Hengqin, Zhuhai, Guangdong, 519031, China. Electronic address: qiuzhihai@gdiist.cn.

PMID: 36130679
DOI: 10.1016/j.brs.2022.09.002

Abstract

Sonogenetics refers to the use of genetically encoded, ultrasound-responsive mediators for noninvasive and selective control of neural activity. It is a promising tool for studying neural circuits. However, due to its infancy, basic studies and developments are still underway, including gauging key in vivo performance metrics such as spatiotemporal resolution, selectivity, specificity, and safety. In this paper, we summarize recent findings on sonogenetics to highlight technical hurdles that have been cleared, challenges that remain, and future directions for optimization.

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Conflict of interest statement

Declaration of competing interest Z.Q., J.G., J. Z., and L.S. have submitted a patent application titled “A Non-invasive method for selective neural stimulation by ultrasound” with the USPTO dated April 10, 2018, assigned application number 15/949,991, which relates to the ultrasound setup used in all the experiments. The authors declare no further financial interests.

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Sonogenetics: Recent advances and future directions

Affiliations

Sonogenetics: Recent advances and future directions

Authors

Affiliations

Abstract

Conflict of interest statement

Publication types

MeSH terms

LinkOut - more resources

Full Text Sources