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. 2023 Nov 22;107(12):1834-1838.
doi: 10.1136/bjo-2022-321716.

Electroretinographic findings in retinal vasculitis

Hashem H Ghoraba  1 , Wataru Matsumiya  1   2 , Christopher Or  1 , Hassan Khojasteh  1 , Prem Patel  1 , Irmak Karaca  1 , Jonathan Regenold  1 , Moosa Zaidi  1 , Jaclyn Hwang  1 , Sherin Lajevardi  1 , Negin Yavari  1 , Ngoc Trong Tuong Than  1 , Sung Who Park  1 , Amir Akhavanrezayat  1 , Gunay Uludag  1 , Cigdem Yasar  1 , Loh-Shan B Leung  1 , Quan Dong Nguyen  3
Affiliations

Electroretinographic findings in retinal vasculitis

Hashem H Ghoraba et al. Br J Ophthalmol. .

Abstract

Aim: To describe and correlate electroretinographic responses with clinical and angiographic findings in retinal vasculitis (RV).

Methods: Medical records of patients with diagnosis of RV at a tertiary eye centre from December 2017 to May 2021 were reviewed. Cases in which fluorescein angiography (FFA) and full field electroretinography (ffERG) were done within 1 month were included. FFAs were graded according to the Angiography Scoring for Uveitis Working Group from 0 to 40, where 0 is normal. A novel ffERG grading system was implemented where individual waves were graded for timing and amplitude and general ffERG score was determined with 6 being a perfect score.

Results: 20 patients (34 eyes) were included. Mean age was 43.9±19.8 years; 70% were female. Median best-corrected visual acuity was 0.8 (0.08-1). Mean FFA score was 12.6±6.5. Median general ffERG score was 5 (0-6). 68% and 91% of eyes had responses with general ffERG scores ≥5 and 4, respectively. Flicker timing was most commonly affected.FFA scores weakly correlated with delayed photopic cone b-wave and flicker timing (p=0.03 and 0.016, respectively). Vitreous haze moderately correlated with delayed cone b-wave timing (p<0.001), delayed flicker timing (p=0.002) and weakly correlated with lower flicker amplitude (p=0.03). Underlying systemic disease was associated with poor ffERG responses.

Conclusion: In this study, RV was not frequently associated with severe global retinal dysfunction Higher FFA scores, and vitreous haze grading were weakly, but significantly, correlated with cone-generated ffERG responses.

Keywords: electrophysiology; inflammation; retina.

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Conflict of interest statement

Competing interests: None declared.

Figures

Figure 1
Figure 1
Consolidated Standards of Reporting Trials Cohort Selection Diagram. ERG, electroretinography.
Figure 2
Figure 2
Frequencies of overall FFA scores. FFA, fundus fluorescein angiography.
Figure 3
Figure 3
Frequencies of average ffERG scores ffERG, full field electroretinography.
Figure 4
Figure 4
Mean scores of individual ffERG responses. ffERG, full field electroretinography.
See this image and copyright information in PMC

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