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Comment
. 2023 Jan;33(1):7-8.
doi: 10.1038/s41422-022-00728-5.

Proviral role of caspase-6 in coronavirus infections

Lok-Yin Roy Wong  1 , Stanley Perlman  2
Affiliations
Comment

Proviral role of caspase-6 in coronavirus infections

Lok-Yin Roy Wong et al. Cell Res. 2023 Jan.
No abstract available

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Figures

Fig. 1
Fig. 1. Proviral role of caspase-6.
MERS-CoV protein, possibly the M protein, sequesters 78-kDa glucose-regulated protein (GRP78) and releases protein kinase R-like endoplasmic reticulum kinase (PERK) for activating PERK-mediated apoptosis. Caspase-6 is activated under apoptotic conditions, presumably by the PERK pathway and cleaves the N protein into IFN-I antagonists that impede IFN regulatory factor 3 (IRF3) translocation into the nucleus for inducing IFN-I expression. The figure was created with BioRender.com.
See this image and copyright information in PMC

Comment on

  • Coronaviruses exploit a host cysteine-aspartic protease for replication.
    Chu H, Hou Y, Yang D, Wen L, Shuai H, Yoon C, Shi J, Chai Y, Yuen TT, Hu B, Li C, Zhao X, Wang Y, Huang X, Lee KS, Luo C, Cai JP, Poon VK, Chan CC, Zhang AJ, Yuan S, Sit KY, Foo DC, Au WK, Wong KK, Zhou J, Kok KH, Jin DY, Chan JF, Yuen KY. Chu H, et al. Nature. 2022 Sep;609(7928):785-792. doi: 10.1038/s41586-022-05148-4. Epub 2022 Aug 3. Nature. 2022. PMID: 35922005

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