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Comment
. 2022 Nov;22(11):606-607.
doi: 10.1038/s41568-022-00515-9.

Gliomas lean on pyrimidines

Joseph Willson  1
Affiliations
Comment

Gliomas lean on pyrimidines

Joseph Willson. Nat Rev Cancer. 2022 Nov.
No abstract available

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Comment on

  • A druggable addiction to de novo pyrimidine biosynthesis in diffuse midline glioma.
    Pal S, Kaplan JP, Nguyen H, Stopka SA, Savani MR, Regan MS, Nguyen QD, Jones KL, Moreau LA, Peng J, Dipiazza MG, Perciaccante AJ, Zhu X, Hunsel BR, Liu KX, Alexandrescu S, Drissi R, Filbin MG, McBrayer SK, Agar NYR, Chowdhury D, Haas-Kogan DA. Pal S, et al. Cancer Cell. 2022 Sep 12;40(9):957-972.e10. doi: 10.1016/j.ccell.2022.07.012. Epub 2022 Aug 18. Cancer Cell. 2022. PMID: 35985342 Free PMC article.
  • De novo pyrimidine synthesis is a targetable vulnerability in IDH mutant glioma.
    Shi DD, Savani MR, Levitt MM, Wang AC, Endress JE, Bird CE, Buehler J, Stopka SA, Regan MS, Lin YF, Puliyappadamba VT, Gao W, Khanal J, Evans L, Lee JH, Guo L, Xiao Y, Xu M, Huang B, Jennings RB, Bonal DM, Martin-Sandoval MS, Dang T, Gattie LC, Cameron AB, Lee S, Asara JM, Kornblum HI, Mak TW, Looper RE, Nguyen QD, Signoretti S, Gradl S, Sutter A, Jeffers M, Janzer A, Lehrman MA, Zacharias LG, Mathews TP, Losman JA, Richardson TE, Cahill DP, DeBerardinis RJ, Ligon KL, Xu L, Ly P, Agar NYR, Abdullah KG, Harris IS, Kaelin WG Jr, McBrayer SK. Shi DD, et al. Cancer Cell. 2022 Sep 12;40(9):939-956.e16. doi: 10.1016/j.ccell.2022.07.011. Epub 2022 Aug 18. Cancer Cell. 2022. PMID: 35985343 Free PMC article.

References

Original article
    1. Pal, S. et al. A druggable addiction to de novo pyrimidine biosynthesis in diffuse midline glioma. Cancer Cell https://doi.org/10.1016/j.ccell.2022.07.012 (2022) - DOI - PubMed
    1. Shi, D. D. et al. Pyrimidine synthesis is a targetable vulnerability in IDH mutant glioma. Cancer Cell https://doi.org/10.1016/j.ccell.2022.07.011 (2022) - DOI - PubMed - PMC

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