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. 2022 Dec;28(4):647-667.
doi: 10.1177/02601060221127853. Epub 2022 Sep 21.

The effects of consuming a Mediterranean style diet on associated COVID-19 severity biomarkers in obese/overweight adults: A systematic review

Ella Moore  1 , Abdulmannan Fadel  1 , Katie E Lane  1
Affiliations

The effects of consuming a Mediterranean style diet on associated COVID-19 severity biomarkers in obese/overweight adults: A systematic review

Ella Moore et al. Nutr Health. 2022 Dec.

Abstract

Background: COVID-19 severity is strongly associated with high Body Mass Index (BMI) (≥25kg/m2) amongst adults and elevated inflammatory markers have enabled prediction of disease progression. The composition of a Mediterranean diet provides favourable outcomes on weight reduction and inflammatory markers. Aim: This systematic review aimed to investigate the effects of consuming a Mediterranean diet on BMI and inflammatory markers of obese/overweight adults (≥18 years) at risk of developing severe COVID-19 outcomes. Methods: PubMed Central, Cochrane Library and MEDLINE databases were searched to identify randomised controlled trials published between January 2010 to August 2021 evaluating the impact of Mediterranean diet on BMI and inflammatory markers in overweight/obese adults. The review followed the PRISMA checklist, used Cochrane Collaboration search strategies, and is PROSPERO registered (CRD42021277070). Two authors independently screened and evaluated studies for methodological quality. Papers were extracted and included based eligibility, despite risk of bias scores. Results: Of 65 extracted records, six studies met the eligibility criteria and were included. Reductions in BMI, TNF-α, IL-6 and hs-CRP were reported amongst most findings, the majority of which were significant. Conclusion: The main findings indicate a hypocaloric, fibre dense Mediterranean diet is a short-term (<4 months) mitigation strategy to significantly reduce BMI and inflammatory markers amongst overweight/obese adults at risk of developing severe COVID-19 outcomes. Further research is now needed to examine the role of Mediterranean diet in COVID-19 prevalence, severity, morbidity and mortality.

Keywords: BMI; COVID-19; Mediterranean diet; biomarkers; hypocaloric diet; non-communicable disease.

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Conflict of interest statement

The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

Figures

Figure 1.
Figure 1.
PRISMA flow diagram. The process of study identification, screening, inclusion and exclusion.
See this image and copyright information in PMC

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References

    1. Academy of Nutrition and Dietetics (2016) Evidence Analysis Manual: Steps in the Academy Evidence Analysis Process. Reportno. Report Number|, Date. Place Published|: Institution|. - PubMed
    1. Agnoli C, Sieri S, Ricceri F, et al. (2018) Adherence to a Mediterranean diet and long-term changes in weight and waist circumference in the EPIC-Italy cohort. Nutrition & Diabetes 8(1): 8–22. - PMC - PubMed
    1. Ajani UA, Ford ES, Mokdad AH. (2004) Dietary fiber and C-reactive protein: Findings from national health and nutrition examination survey data. Journal of Nutrition 134(5): 1181–1185. - PubMed
    1. Al-Daghri NM, Rahman S, Sabico S, et al. (2016) Association of vitamin B12 with pro-inflammatory cytokines and biochemical markers related to cardiometabolic risk in Saudi subjects. Nutrients 8(9): 460. - PMC - PubMed
    1. Al-Quteimat OM, Amer AM. (2020) The impact of the COVID-19 pandemic on cancer patients. American Journal of Clinical Oncology 43(6): 452–455. - PMC - PubMed

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