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. 2022 Dec;26(8):e14394.
doi: 10.1111/petr.14394. Epub 2022 Sep 22.

Impact of multiorgan and kidney-pancreas allocation policies on pediatric kidney-alone transplant candidates in the United States

Rachel Engen  1 , Danielle Shepherd  2 , Miranda C Bradford  3 , Julia Foutz  4 , Sharon M Bartosh  5 , Jodi M Smith  6
Affiliations

Impact of multiorgan and kidney-pancreas allocation policies on pediatric kidney-alone transplant candidates in the United States

Rachel Engen et al. Pediatr Transplant. 2022 Dec.

Abstract

Background: The United States organ allocation policies prioritize kidney-pancreas and other multiorgan candidates above pediatric kidney-alone candidates, but the effects of these policies are unclear.

Methods: We used OPTN data to describe trends in multiorgan and kidney-pancreas transplantation and identify 377 next-sequential pediatric kidney-alone candidates between 4/1/2015 and 10/31/2019 for individual-level analysis.

Results: Eleven percent of all kidneys were allocated as part of a multiorgan or kidney-pancreas transplant and 6% of pediatric kidney candidates were impacted. Pediatric next-sequential candidates accrued a median of 118 days (IQR 97-135 days) of additional wait time, and this was significantly longer for children who were Hispanic (p = .02), blood type B or O (p = .01), or had a cPRA ≥20% (p < .01). Eight pediatric next-sequential candidates (2%) were removed from the waitlist due to death or "too sick to transplant." 63% were transplanted with a kidney with a higher KDPI than the original multiorgan match (p < .01). Donor service areas with higher volumes of kidney-pancreas transplants had significantly longer additional wait times for pediatric next-sequential candidates (p = .01).

Conclusions: Current allocation policy results in longer waiting times and higher KDPI kidneys for pediatric kidney candidates. As multiorgan transplant volume is increasing, further consideration of allocation policy is necessary to maximize equality and utility.

Keywords: allocation; kidney; multiorgan transplant; pediatrics.

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References

REFERENCES

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    1. OPTN. Ethical Implications of Multi-Organ Transplants OPTN Ethics Committee. OPTN; 2019.
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    1. OPTN. Ethical principles of pediatric organ allocation. https://optn.transplant.hrsa.gov/resources/ethics/ethical-principles-of-.... Accessed June 23, 2021.