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. 2022 Sep 2;13(3):139.
doi: 10.3390/jfb13030139.

ZnO/CeO2 Nanocomposites: Metal-Organic Framework-Mediated Synthesis, Characterization, and Estimation of Cellular Toxicity toward Liver Cancer Cells

Toqa Alabyadh  1 , Riyadh Albadri  1 , Ali Es-Haghi  1 , Mohammad Ehsan Taghavizadeh Yazdi  2 , Narges Ajalli  3 , Abbas Rahdar  4 , Vijay Kumar Thakur  5   6   7   8
Affiliations

ZnO/CeO2 Nanocomposites: Metal-Organic Framework-Mediated Synthesis, Characterization, and Estimation of Cellular Toxicity toward Liver Cancer Cells

Toqa Alabyadh et al. J Funct Biomater. .

Abstract

The Zinc-doped cerium oxide nanocomposite (ZnO/CeO2 NC) was synthesized using a metal-organic framework as a precursor through the combustion method. It was characterized by powder X-ray diffraction (PXRD), Fourier transform infrared spectroscopy (FTIR), field emission electron microscopy (FESEM), energy dispersive analysis (EDX), transmission electron microscopy (TEM), dynamic light scattering (DLS), and ξ-potential. The PXRD demonstrated the successful synthesis of ZnO/CeO2 NC with a crystallite size of 31.9 nm. FESEM and TEM images displayed hexagonal and spherical morphologies, and the solid-phase size was 65.03 ± 30.86 nm for ZnO/CeO2 NCs. DLS, TEM, and FESEM showed that the NCs have a high tendency for agglomeration/aggregation in both aqueous media and solid phase. The anticancer attributes of ZnO/CeO2 NC were investigated against Liver cancer cells (HepG2), which showed inhibition of cancer cell growth on a concentration-dependent gradient. The cell toxicity effects of ZnO/CeO2 nanocomposites were also studied toward NIH-3T3, in which the data displayed the lower toxicity of NC compared to the HepG2 cell line.

Keywords: anticancer; cerium oxide; doping; metal-organic framework; nanoceria; zinc oxide.

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Conflict of interest statement

The authors declare that there are no conflict of interest.

Figures

Figure 1
Figure 1
Pictorial diagram for synthetic procedure.
Figure 2
Figure 2
The FTIR spectrum of the ZnO/CeO2 NCs.
Figure 3
Figure 3
PXRD analyses of the CeO2 NPs and ZnO/CeO2 NCs.
Figure 4
Figure 4
(a–c) FESEM images and (d) EDX analysis of the ZnO/CeO2 NCs.
Figure 5
Figure 5
(a–c) FESEM images and (d) particle size distribution of the ZnO/CeO2 NCs.
Figure 6
Figure 6
The hydrodynamic size dispersion of the ZnO/CeO2 NCs by intensity and number.
Figure 7
Figure 7
Comparative diagram of cytotoxicity properties of fabricated (b) ZnO/CeO2, (d) ZnO, (f) CeO2 NCs against NIH-3T3 and cytotoxicity properties of (a) fabricated ZnO/CeO2, (c) ZnO, (e) CeO2 NCs against HepG2. The percentages were displayed relative to control cells. * p < 0.05, ** p < 0.01, *** p < 0.001 indicated significant difference as compared to the control.
Figure 8
Figure 8
The cytotoxicity effect of doxorubicin against NIH-3T3 and HepG2. ** p < 0.01, *** p < 0.001 indicated significant difference as compared to the control.
See this image and copyright information in PMC

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