The Many Faces of Astrocytes in the Septic Brain

doi:10.1007/s12035-022-03027-7

Review

. 2022 Dec;59(12):7229-7235.

doi: 10.1007/s12035-022-03027-7. Epub 2022 Sep 22.

The Many Faces of Astrocytes in the Septic Brain

Lucinéia Gainski Danielski^{1

2}, Amanda Della Giustina³, Fernanda Frederico Gava², Tatiana Barichello^{4

5}, Fabricia Petronilho⁶

Affiliations

¹ Laboratory of Neurobiology of Inflammatory and Metabolic Processes, Graduate Program in Health Sciences, Health Sciences Unit, University of South Santa Catarina, Tubarao, SC, Brazil.
² Laboratory of Experimental Neurology, Graduate Program in Health Sciences, Health Sciences Unit, University of Southern Santa Catarina, Criciuma, SC, Brazil.
³ School of Nutrition Sciences, Faculty of Health Sciences, University of Ottawa, Ottawa, Canada.
⁴ Laboratory of Experimental Pathophysiology, Graduate Program in Health Sciences, Health Sciences Unit, University of Southern Santa Catarina, Criciuma, SC, Brazil.
⁵ Faillace Department of Psychiatry and Behavioral Sciences, McGovern Medical School, Translational Psychiatry Program, The University of Texas Health Science Center at Houston (UTHealth), Houston, TX, 77054, USA.
⁶ Laboratory of Experimental Neurology, Graduate Program in Health Sciences, Health Sciences Unit, University of Southern Santa Catarina, Criciuma, SC, Brazil. fabriciapetronilho@unesc.net.

PMID: 36136265
DOI: 10.1007/s12035-022-03027-7

Review

The Many Faces of Astrocytes in the Septic Brain

Lucinéia Gainski Danielski et al. Mol Neurobiol. 2022 Dec.

. 2022 Dec;59(12):7229-7235.

doi: 10.1007/s12035-022-03027-7. Epub 2022 Sep 22.

Authors

Lucinéia Gainski Danielski^{1

2}, Amanda Della Giustina³, Fernanda Frederico Gava², Tatiana Barichello^{4

5}, Fabricia Petronilho⁶

Affiliations

¹ Laboratory of Neurobiology of Inflammatory and Metabolic Processes, Graduate Program in Health Sciences, Health Sciences Unit, University of South Santa Catarina, Tubarao, SC, Brazil.
² Laboratory of Experimental Neurology, Graduate Program in Health Sciences, Health Sciences Unit, University of Southern Santa Catarina, Criciuma, SC, Brazil.
³ School of Nutrition Sciences, Faculty of Health Sciences, University of Ottawa, Ottawa, Canada.
⁴ Laboratory of Experimental Pathophysiology, Graduate Program in Health Sciences, Health Sciences Unit, University of Southern Santa Catarina, Criciuma, SC, Brazil.
⁵ Faillace Department of Psychiatry and Behavioral Sciences, McGovern Medical School, Translational Psychiatry Program, The University of Texas Health Science Center at Houston (UTHealth), Houston, TX, 77054, USA.
⁶ Laboratory of Experimental Neurology, Graduate Program in Health Sciences, Health Sciences Unit, University of Southern Santa Catarina, Criciuma, SC, Brazil. fabriciapetronilho@unesc.net.

PMID: 36136265
DOI: 10.1007/s12035-022-03027-7

Abstract

Sepsis is a life-threatening organ dysfunction that is caused by a dysregulated host response to infection. Surviving patients have cognitive and memory damage that started during sepsis. These neurologic damages have been associated with increased BBB permeability and microglial activation. However, a few discrete studies have seen over the years pointing to the potential role of astrocytes in the pathophysiology of neurological damage after sepsis. The purpose of this article is to review information on the potential role of astrocytes during sepsis, as well as to provoke further studies in this area. These published articles show astrocytic activation after sepsis; they also evidence the release of inflammatory mediators by these cells. In this sense, the role of astrocytes should be better elucidated during sepsis progression.

Keywords: Astrocytes; Brain; Delirium; Neuroinflammation; Sepsis-associated encephalopathy.

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References

1. Van Der Poll T, Van De Veerdonk FL, Scicluna BP, Netea MG (2017) The immunopathology of sepsis and potential therapeutic targets. Nat Rev Immunol 17(7):407–420. https://doi.org/10.1038/nri.2017.36
1. Rudd KE, Johnson SC, Agesa KM et al (2020) Global, regional, and national sepsis incidence and mortality, 1990–2017: analysis for the Global Burden of Disease Study. The Lancet 395:200–211. https://doi.org/10.1016/S0140-6736(19)32989-7 - DOI
1. Danielski LG, Giustinadella A, Badawy M et al (2018) Brain barrier breakdown as a cause and consequence of neuroinflammation in sepsis. Mol Neurobiol 55:1045–1053. https://doi.org/10.1007/s12035-016-0356-7 - DOI - PubMed
1. Barichello T, Generoso JS, Collodel A et al (2021) The blood-brain barrier dysfunction in sepsis. Tissue Barriers 9. https://doi.org/10.1080/21688370.2020.1840912
1. Mazeraud A, Righy C, Bouchereau E et al (2020) Septic-associated encephalopathy: a comprehensive review. Neurotherapeutics 17:392–403. https://doi.org/10.1007/S13311-020-00862-1 - DOI - PubMed - PMC

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[1] Van Der Poll T, Van De Veerdonk FL, Scicluna BP, Netea MG (2017) The immunopathology of sepsis and potential therapeutic targets. Nat Rev Immunol 17(7):407–420. https://doi.org/10.1038/nri.2017.36

[2] Van Der Poll T, Van De Veerdonk FL, Scicluna BP, Netea MG (2017) The immunopathology of sepsis and potential therapeutic targets. Nat Rev Immunol 17(7):407–420. https://doi.org/10.1038/nri.2017.36

[3] Rudd KE, Johnson SC, Agesa KM et al (2020) Global, regional, and national sepsis incidence and mortality, 1990–2017: analysis for the Global Burden of Disease Study. The Lancet 395:200–211. https://doi.org/10.1016/S0140-6736(19)32989-7 - DOI

[4] Rudd KE, Johnson SC, Agesa KM et al (2020) Global, regional, and national sepsis incidence and mortality, 1990–2017: analysis for the Global Burden of Disease Study. The Lancet 395:200–211. https://doi.org/10.1016/S0140-6736(19)32989-7 - DOI

[5] Danielski LG, Giustinadella A, Badawy M et al (2018) Brain barrier breakdown as a cause and consequence of neuroinflammation in sepsis. Mol Neurobiol 55:1045–1053. https://doi.org/10.1007/s12035-016-0356-7 - DOI - PubMed

[6] Danielski LG, Giustinadella A, Badawy M et al (2018) Brain barrier breakdown as a cause and consequence of neuroinflammation in sepsis. Mol Neurobiol 55:1045–1053. https://doi.org/10.1007/s12035-016-0356-7 - DOI - PubMed

[7] Barichello T, Generoso JS, Collodel A et al (2021) The blood-brain barrier dysfunction in sepsis. Tissue Barriers 9. https://doi.org/10.1080/21688370.2020.1840912

[8] Barichello T, Generoso JS, Collodel A et al (2021) The blood-brain barrier dysfunction in sepsis. Tissue Barriers 9. https://doi.org/10.1080/21688370.2020.1840912

[9] Mazeraud A, Righy C, Bouchereau E et al (2020) Septic-associated encephalopathy: a comprehensive review. Neurotherapeutics 17:392–403. https://doi.org/10.1007/S13311-020-00862-1 - DOI - PubMed - PMC

[10] Mazeraud A, Righy C, Bouchereau E et al (2020) Septic-associated encephalopathy: a comprehensive review. Neurotherapeutics 17:392–403. https://doi.org/10.1007/S13311-020-00862-1 - DOI - PubMed - PMC

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The Many Faces of Astrocytes in the Septic Brain

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The Many Faces of Astrocytes in the Septic Brain

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