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Review
. 2022 Dec;59(12):7229-7235.
doi: 10.1007/s12035-022-03027-7. Epub 2022 Sep 22.

The Many Faces of Astrocytes in the Septic Brain

Lucinéia Gainski Danielski  1   2 , Amanda Della Giustina  3 , Fernanda Frederico Gava  2 , Tatiana Barichello  4   5 , Fabricia Petronilho  6
Affiliations
Review

The Many Faces of Astrocytes in the Septic Brain

Lucinéia Gainski Danielski et al. Mol Neurobiol. 2022 Dec.

Abstract

Sepsis is a life-threatening organ dysfunction that is caused by a dysregulated host response to infection. Surviving patients have cognitive and memory damage that started during sepsis. These neurologic damages have been associated with increased BBB permeability and microglial activation. However, a few discrete studies have seen over the years pointing to the potential role of astrocytes in the pathophysiology of neurological damage after sepsis. The purpose of this article is to review information on the potential role of astrocytes during sepsis, as well as to provoke further studies in this area. These published articles show astrocytic activation after sepsis; they also evidence the release of inflammatory mediators by these cells. In this sense, the role of astrocytes should be better elucidated during sepsis progression.

Keywords: Astrocytes; Brain; Delirium; Neuroinflammation; Sepsis-associated encephalopathy.

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References

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