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. 2022 Sep 13;7(9):244.
doi: 10.3390/tropicalmed7090244.

The Characteristics and Patterns of Drug-Resistant Pulmonary Tuberculosis in Eastern India

Vishal Prakash Giri  1 , Om Prakash Giri  2 , Pooja Tripathi Pandey  3 , Kripa Nath Mishra  4 , Ram Shanker Prasad  5 , Prabhat Kumar Lal  6 , Rana Pratap  7 , Nishant Nikhil  8 , Abu Sufian  8 , Reyaz Ahmad  8 , Shubhra Kanodia  9
Affiliations

The Characteristics and Patterns of Drug-Resistant Pulmonary Tuberculosis in Eastern India

Vishal Prakash Giri et al. Trop Med Infect Dis. .

Abstract

Background: Drug-resistant tuberculosis is a major public health problem throughout the world and accounts for substantial morbidity and mortality rates in India, too. Early diagnosis is the corner stone of tuberculosis treatment. State-level and cluster-wise variations in drug resistance is a possibility and should be regularly checked in from time to time.

Materials and methods: The present prospective cohort study (January 2019 to May 2022) was conducted in Darbhanga Medical College and Hospital on drug-resistant pulmonary tuberculosis patients. Sputum specimens were collected from designated centers. Rapid molecular drug-resistance testing (genotypic tests) and growth-based drug-susceptibility testing (DST) (phenotypic tests) were performed in the National Tuberculosis Elimination Program certified Laboratory.

Results: A total of 268 patients with drug-resistant pulmonary tuberculosis were included in the study group. The treatment outcomes revealed as cured in 100 (37.31%); treatment completed in 43 (16.04%); died in 56 (20.89%); treatment failed in 22 (8.21%); loss of follow up in 34 (12.69%); and transferred out in 13 (4.85%) drug-resistant pulmonary tuberculosis patients. Adverse events were recorded in 199 (74.25%) of the drug-resistant pulmonary tuberculosis patients.

Conclusions: Drug-resistant pulmonary tuberculosis patients are a matter of concern and need to be addressed.

Keywords: adverse drug events; drug resistance; drug-resistant tuberculosis; extensively drug-resistant tuberculosis; multi-drug-resistant tuberculosis; national tuberculosis elimination program; treatment outcome.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Flowchart—drug-resistant TB diagnosis.
See this image and copyright information in PMC

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