Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
. 2022 Sep 9;12(5):734-737.
doi: 10.3390/clinpract12050076.

Efficacy of Naproxen/Fexofenadine (SJP-003) in the Prevention of Side Effects of Influenza Vaccination: Four Case Studies

Pantea Kiani  1 , Thomas A Dahl  2 , Jacqueline M Iversen  2 , Andrew Scholey  3 , Joris C Verster  1   4
Affiliations
Case Reports

Efficacy of Naproxen/Fexofenadine (SJP-003) in the Prevention of Side Effects of Influenza Vaccination: Four Case Studies

Pantea Kiani et al. Clin Pract. .

Abstract

The influenza virus is associated with sickness, and in particular among vulnerable populations such as elderly and those with underlying disease with hospitalization and increased mortality rates. Vaccination is an effective way to prevent infection with influenza. However, undesirable side effects of the vaccination are commonly experienced, and comprise one of the primary reasons for a substantial group of individuals to refrain from vaccination. An effective treatment against vaccination side effects could increase the overall willingness to vaccinate against influenza. Here, four cases are presented that self-administered SJP-003 (a combination of 220 mg naproxen sodium, directly followed by a single oral dose of 60 mg fexofenadine HCL), 2 h before and 10 h after influenza vaccination. No flu-like symptoms and pain at the injection site were reported. These observations warrant further investigation of SJP-003 in double-blind, placebo-controlled clinical trials.

Keywords: SJP-003; fexofenadine; flu-like symptoms; influenza; naproxen; pain at injection site; side effects; vaccination; willingness to vaccinate.

PubMed Disclaimer

Conflict of interest statement

Over the past 36 months, A.S. has held research grants from Abbott Nutrition, Arla Foods, Bayer, BioRevive, DuPont, Fonterra, Kemin Foods, Nestlé, Nutricia-Danone, and Verdure Sciences. He has acted as a consultant/expert advisor to Arepa Nootroptics, Bayer, Coca-Cola, Danone, Naturex, Nestlé, Pfizer, Sanofi, Sen-Jam Pharmaceutical, and has received travel/hospitality/speaker fees from Bayer, Sanofi, and Verdure Sciences. Over the past 36 months, J.C.V. has acted as a consultant/expert advisor to KNMP, Mentis, Red Bull, Sen-Jam Pharmaceutical, and Toast!. T.A.D. is partner and Head of Product Development and Regulatory Affairs of Sen-Jam Pharmaceutical. J.M.I. is founder and Head of Clinical Development of Sen-Jam Pharmaceutical. P.K. has nothing to declare.

References

    1. Mezlini A., Shapiro A., Daza E.J., Caddigan E., Ramirez E., Althoff T., Foschini L. Estimating the Burden of Influenza-like Illness on Daily Activity at the Population Scale Using Commercial Wearable Sensors. JAMA Netw. Open. 2022;5:e2211958. doi: 10.1001/jamanetworkopen.2022.11958. - DOI - PMC - PubMed
    1. Centers for Disease Control and Prevention Burden of Flu. [(accessed on 28 May 2022)]; Available online: https://www.cdc.gov/flu/about/burden/preliminary-in-season-estimates.htm.
    1. World Health Organisation Influenza (Seasonal) [(accessed on 28 May 2022)]. Available online: https://www.who.int/news-room/fact-sheets/detail/influenza-(seasonal)
    1. Fiore A.E., Bridges C.B., Cox N.J. Seasonal influenza vaccines. Curr. Top. Microbiol. Immunol. 2009;333:43–82. - PubMed
    1. Kalligeros M., Shehadeh F., Mylona E.K., Dapaah-Afriyie C., van Aalst R., Chit A., Mylonakis E. Influenza vaccine effectiveness against influenza-associated hospitalization in children: A systematic review and meta-analysis. Vaccine. 2020;38:2893–2903. doi: 10.1016/j.vaccine.2020.02.049. - DOI - PubMed

Publication types

LinkOut - more resources