Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2022 Sep 22;17(9):e0264545.
doi: 10.1371/journal.pone.0264545. eCollection 2022.

Continuous subcutaneous insulin infusion is associated with a better glycemic control than multiple daily insulin injections without difference in diabetic ketoacidosis and hypoglycemia admissions among Emiratis with Type 1 diabetes

Raya Almazrouei  1   2 , Charu Sharma  2 , Bachar Afandi  1 , Khaled M Aldahmani  1   2 , Elhadi H Aburawi  3 , Salem A Beshyah  4 , Gehad ElGhazali  5 , Zain Al Yafei  6 , Rami H Al-Rifai  7 , Juma Alkaabi  2
Affiliations

Continuous subcutaneous insulin infusion is associated with a better glycemic control than multiple daily insulin injections without difference in diabetic ketoacidosis and hypoglycemia admissions among Emiratis with Type 1 diabetes

Raya Almazrouei et al. PLoS One. .

Abstract

Aims: To characterizes Emiratis patients with Type 1 diabetes (T1D) and compares outcomes between continuous subcutaneous insulin infusion (CSII) versus multiple daily insulin injections (MDI) users. The WHO-Five Well-Being Index (WHO-5) score was used to screen for depression.

Methods: In this cross-sectional study; sociodemographic, clinical characteristics and insulin replacement regimens were collected on patients with T1D between 2015-2018.

Results: 134 patients with mean age of 20.9±7.5 years were included. Females constitute 56.7% and 50.7% had diabetes duration of >10 years. Diabetic ketoacidosis (DKA) at presentation was reported in 46.3%. Average glycemic control over preceding 12months was satisfactory (less than 7.5%), suboptimal (7.5-9%), and poor (more than 9%) in 26.6%, 42.7% & 30.6% of the patients, respectively. Higher proportion of patients using CSII achieved satisfactory or suboptimal glycemic control compared to patients with MDI (P = 0.003). The latest median /IQR HbA1c was significantly lower (P = 0.041) in patients using CSII (8.2 /1.93%) compared to MDI (8.5/2.45%). There was no significant difference between two groups in DKA, severe hypoglycemia or total WHO-5 score.

Conclusions: CSII usage was associated with better glycemic control than MDI, although no difference in DKA and severe hypoglycemia. The overall glycemic control among Emiratis subjects with T1D is unsatisfactory and needs more rigorous patient counseling and education.

PubMed Disclaimer

Conflict of interest statement

The authors have declared that no competing interests exist.

References

    1. Huang Y. IDF Diabetes Atlas 8th Edition 2017.
    1. Zayed H. Genetic Epidemiology of Type 1 Diabetes in the 22 Arab Countries. Current diabetes reports. 2016;16. doi: 10.1007/s11892-016-0736-4 . - DOI - PubMed
    1. Shaltout AA, Channanath AM, Thanaraj TA, Omar D, Abdulrasoul M, Zanaty N, et al. Ketoacidosis at first presentation of type 1 diabetes mellitus among children: a study from Kuwait. Sci Rep. 2016. 22; 6:27519. doi: 10.1038/srep27519 . - DOI - PMC - PubMed
    1. Dabelea D. The accelerating epidemic of childhood diabetes. Lancet. 2009. Jun 13; 373:1999–2000. doi: 10.1016/S0140-6736(09)60874-6 . - DOI - PubMed
    1. Al-Hassani N, Chedid F, Hadi S, Kaplan W. Prevalence of autoantibodies in type 1 diabetes patients and its association with the clinical presentation—UAE Eastern Region experience. J Pediatr Endocrinol Metab. 2014;27:1157–9. doi: 10.1515/jpem-2013-0430 . - DOI - PubMed

Publication types