Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2023 Jun;51(3):655-664.
doi: 10.1007/s15010-022-01917-5. Epub 2022 Sep 22.

Assessment of COVID -19 associated coagulopathy and multiple hemostatic markers: a single center study in Egypt

Azza Abdelaal  1 , Ahmed Abu-Elfatth  2 , Lamees M Bakkar  3 , Hanan G Abd El-Azeem  1 , Helal F Hetta  4 , Eman R Badawy  1
Affiliations

Assessment of COVID -19 associated coagulopathy and multiple hemostatic markers: a single center study in Egypt

Azza Abdelaal et al. Infection. 2023 Jun.

Abstract

Background: Coagulopathy is still a serious pattern of coronavirus-19 disease. We aimed to evaluate COVID-19-associated coagulopathy and multiple hemostatic markers in Egyptian patients. In addition, to assess coagulation acute phase reactants and its effect on the outcome.

Methods: The study included 106 COVID-19 patients, and 51 controls. All patients were positive for COVID-19 infection by nasopharyngeal swab for detection of viral RNA by real-time PCR. In addition to baseline data and radiological findings, the coagulation profile was done with special attention to Fibrinogen, D-dimer, Factor VIII, von Willebrand factor (VWF), Protein C, Protein S, Antithrombin III (ATIII) and Lupus anticoagulant (LA)-1 and 2.

Results: The results showed significantly higher VWF, D-dimer, and LA1 (screening) and LA2 (confirmation) in patients than a control group. Significantly higher D-dimer FVIII, VWF and LA1-2 were detected in the severe group. ATIII had high diagnostic accuracy in severity prediction. We found a significantly higher international randomized ratio (INR) and VWF among patients with thrombotic events. For prediction of thrombosis; VWF at cutoff > 257.7 has 83.3% sensitivity and 83.3% specificity.

Conclusion: Patients with COVID-19 infection are vulnerable to different forms of coagulopathy. This could be associated with poor outcomes. D-Dimer is a chief tool in diagnosis, severity evaluation but not thrombosis prediction. Early screening for this complication and its proper management would improve the outcome.

Keywords: COVID-19; Coagulopathy; Egypt; Thrombosis.

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflict of interest.

Figures

Fig. 1
Fig. 1
Accuracy of VWF and LA-1 in diagnosis of COVID-19
Fig. 2
Fig. 2
Accuracy of LA-1, ATIII, and VWF for prediction of COVID-19 severity
Fig. 3
Fig. 3
Accuracy of VWF in prediction of thrombotic events in COVID-19
Fig. 4
Fig. 4
Correlation between LA-1 and CRP among COVID-19 patients
Fig. 5
Fig. 5
Correlation between LA-2 and CRP among COVID-19 patients
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Gomez-Mesa JE, Galindo-Coral S, Montes MC, Martin AJM. Thrombosis and coagulopathy in COVID-19. Curr Probl Cardiol. 2021;46:100742. doi: 10.1016/j.cpcardiol.2020.100742. - DOI - PMC - PubMed
    1. Iba T, Levy JH, Levi M, Thachil J. Coagulopathy in COVID-19. J Thromb Haemost. 2020;18:2103–2109. doi: 10.1111/jth.14975. - DOI - PMC - PubMed
    1. Mousa N, Abdel-Razik A, Mousa E, Elbadrawy T, Hosni K, Mousa A, et al. Coagulopathy in COVID-19 from pathogenesis until treatment: a systemic review. Med J Viral Hepat. 2021;5:3–8. doi: 10.21608/mjvh.2021.158270. - DOI
    1. Jayarangaiah A, Kariyanna PT, Chen X, Jayarangaiah A, Kumar A. COVID-19-associated coagulopathy: an exacerbated immunothrombosis response. Clin Appl Thromb Hemost. 2020;26:1076029620943293. doi: 10.1177/1076029620943293. - DOI - PMC - PubMed
    1. Portier I, Campbell RA, Denorme F. Mechanisms of immunothrombosis in COVID-19. Curr Opin Hematol. 2021;28:445–453. doi: 10.1097/moh.0000000000000666. - DOI - PMC - PubMed