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. 2022 Sep 3;9(9):1347.
doi: 10.3390/children9091347.

The Economic Burden of Pneumococcal Disease in Children: A Population-Based Investigation in the Veneto Region of Italy

Elisa Barbieri  1 , Gloria Porcu  2 , Tanaz Petigara  3 , Francesca Senese  4 , Gian Marco Prandi  4 , Antonio Scamarcia  5 , Luigi Cantarutti  5 , Anna Cantarutti  2 , Carlo Giaquinto  1   5
Affiliations

The Economic Burden of Pneumococcal Disease in Children: A Population-Based Investigation in the Veneto Region of Italy

Elisa Barbieri et al. Children (Basel). .

Abstract

Despite widespread childhood immunization programs, pneumococcal disease (PD) continues to be associated with significant clinical and economic burden worldwide. This retrospective study assessed the PD-related economic burden in children from the Veneto region of Italy following the introduction of a 13-valent pneumococcal conjugate vaccine (PCV13) to the Italian immunization schedule in 2010. Between 2010 and 2017, the annual incidences of pneumonia, acute otitis media (AOM), and invasive pneumococcal disease (IPD), as well as syndromic-disease-related episodes, declined. In our analysis of data from regional expenditure and healthcare resource utilization (HCRU) databases related to children < 15 years of age, we found that regional expenditures decreased between 2010 and 2017 for pneumonia (EUR 8.88 to EUR 3.59 million), AOM (EUR 3.78 to EUR 2.76 million), and IPD (EUR 1.40 to EUR 1.00 million). Despite reductions in PD-related expenditure following the introduction of PCV13, there continues to be an economic burden associated with PD in Veneto, Italy.

Keywords: Italy; acute otitis media; economic burden; healthcare resource utilization; invasive pneumococcal disease; pneumococcal disease; pneumonia.

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Conflict of interest statement

Gian Marco Prandi and Francesca Senese are employees of MSD Italia. Tanaz Petigara is an employee of Merck Sharp &amp; Dohme LLC, a subsidiary of Merck &amp; Co., Inc., Rahway, NJ, USA, and may own stock and/or hold stock options in Merck &amp; Co., Inc., Rahway, NJ, USA. All other authors and contributors have no relevant financial or non-financial interests to disclose.

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