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Review
. 2022 Sep 16;11(9):1830.
doi: 10.3390/antiox11091830.

NADPH Oxidases in Aortic Aneurysms

Morgan Salmon  1
Affiliations
Review

NADPH Oxidases in Aortic Aneurysms

Morgan Salmon. Antioxidants (Basel). .

Abstract

Abdominal aortic aneurysms (AAAs) are a progressive dilation of the infrarenal aorta and are characterized by inflammatory cell infiltration, smooth muscle cell migration and proliferation, and degradation of the extracellular matrix. Oxidative stress and the production of reactive oxygen species (ROS) have been shown to play roles in inflammatory cell infiltration, and smooth muscle cell migration and apoptosis in AAAs. In this review, we discuss the principles of nicotinamide adenine dinucleotide phosphate oxidase (NADPH oxidase/NOX) signaling and activation. We also discuss the effects of some of the major mediators of NOX signaling in AAAs. Separately, we also discuss the influence of genetic or pharmacologic inhibitors of NADPH oxidases on experimental pre-clinical AAAs. Experimental evidence suggests that NADPH oxidases may be a promising future therapeutic target for developing pharmacologic treatment strategies for halting AAA progression or rupture prevention in the management of clinical AAAs.

Keywords: NADPH oxidases/NOX; aortic aneurysm; reactive oxygen species.

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Conflict of interest statement

The author declares no conflict of interest, and the funders had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript; or in the decision to publish the results.

Figures

Figure 1
Figure 1
Structure of the Nox family members’ complexes. Created using Biorender.com and adapted from [50].
See this image and copyright information in PMC

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