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Review
. 2022 Sep 8;10(9):2223.
doi: 10.3390/biomedicines10092223.

Nephron-Sparing Approaches in Upper Tract Urothelial Carcinoma: Current and Future Strategies

Won Sik Ham  1 , Jee Soo Park  1   2 , Won Sik Jang  1 , Jongchan Kim  1   3
Affiliations
Review

Nephron-Sparing Approaches in Upper Tract Urothelial Carcinoma: Current and Future Strategies

Won Sik Ham et al. Biomedicines. .

Abstract

Upper tract urothelial carcinoma (UTUC) is a relatively rare cancer, and much of the approach to treatment has been derived from strategies employed in treating bladder cancer. Radical nephroureterectomy (RNU) is regarded as the gold standard treatment for UTUC. However, due to potential complications, such as renal function impairment, that can affect oncologic outcomes, the demand for nephron-sparing treatment to effectively treat cancer while preserving renal function has increased. As a result, various treatment methods for low-grade, low-volume UTUC, such as segmental ureterectomy, endoscopic resection, and intraluminal therapy, have been attempted and reported. Although these treatment modalities have exhibited acceptable oncological results, further studies are required. In the future, the introduction of new technologies, such as improved diagnostic and surgical equipment, and new drug delivery systems, could enhance the effectiveness of nephron-sparing strategies in the treatment of UTUC. Additionally, understanding the biological and genetic characteristics of UTUC that distinguish it from those of bladder cancer will also aid in establishing strategies for nephron-sparing.

Keywords: kidney function; nephron-sparing; upper urinary tract; urothelial carcinoma.

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Conflict of interest statement

The authors declare no conflict of interest.

References

    1. Siegel R.L., Miller K.D., Fuchs H.E., Jemal A. Cancer statistics, 2021. CA Cancer J. Clin. 2021;71:7–33. doi: 10.3322/caac.21654. - DOI - PubMed
    1. Rouprêt M., Babjuk M., Burger M., Capoun O., Cohen D., Compérat E.M., Cowan N.C., Dominguez-Escrig J.L., Gontero P., Hugh Mostafid A., et al. European association of urology guidelines on upper urinary tract urothelial carcinoma: 2020 update. Eur. Urol. 2021;79:62–79. doi: 10.1016/j.eururo.2020.05.042. - DOI - PubMed
    1. National Comprehensive Cancer Network Bladder Cancer (Version 2.2022) [(accessed on 7 September 2022)]. Available online: https://www.nccn.org/professionals/physician_gls/pdf/bladder.pdf.
    1. Veccia A., Antonelli A., Francavilla S., Simeone C., Guruli G., Zargar H., Perdoná S., Ferro M., Carrieri G., Hampton L.J., et al. Robotic versus other nephroureterectomy techniques: A systematic review and meta-analysis of over 87,000 cases. World J. Urol. 2020;38:845–852. doi: 10.1007/s00345-019-03020-1. - DOI - PubMed
    1. Nazzani S., Bazinet A., Preisser F., Mazzone E., Tian Z., Mistretta F.A., Shariat S.F., Saad F., Zorn K.C., Montanari E., et al. Comparison of perioperative outcomes between open and minimally invasive nephroureterectomy: A population-based analysis. Int. J. Urol. 2019;26:487–492. doi: 10.1111/iju.13916. - DOI - PubMed