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Review
. 2022 Aug 26;13(9):1537.
doi: 10.3390/genes13091537.

Circular RNAs: New Players in Cardiomyopathy

Maedeh Bagheri Moghaddam  1   2 , Majid Maleki  2 , Maziar Oveisee  3 , Mahrokh Bagheri Moghaddam  2 , Maedeh Arabian  2 , Mahshid Malakootian  2
Affiliations
Review

Circular RNAs: New Players in Cardiomyopathy

Maedeh Bagheri Moghaddam et al. Genes (Basel). .

Abstract

Cardiomyopathies comprise a heterogeneous group of cardiac diseases identified by myocardium disorders and diminished cardiac function. They often lead to heart failure or heart transplantation and constitute one of the principal causes of morbidity and mortality worldwide. Circular RNAs (circRNAs) are a novel type of noncoding RNAs. They are covalently closed and single-stranded and derived from the exons and introns of genes by alternative splicing. This specific structure renders them resistant to exonuclease digestion. Many recent studies have demonstrated that circRNAs are highly abundant and conserved and can play central roles in biological functions such as microRNA (miRNA) sponging, splicing, and transcription regulation. Emerging evidence indicates that circRNAs can play significant roles in cardiovascular diseases, including cardiomyopathies. In this review, we briefly describe the current understanding regarding the classification, nomenclature, characteristics, and function of circRNAs and report recent significant findings concerning the roles of circRNAs in cardiomyopathies. Furthermore, we discuss the clinical application potential of circRNAs as the therapeutic targets and diagnostic biomarkers of cardiomyopathies.

Keywords: cardiomyopathy; ceRNA; circular RNAs; non-coding RNAs.

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Conflict of interest statement

The authors do not have existing conflict of interest.

Figures

Figure 1
Figure 1
The image depicts the classification of ncRNAs: rRNA, ribosomal RNA; tRNA, transfer RNA; snRNA, small nuclear RNA; snoRNA, small nucleolar RNA; miRNA, microRNA; siRNA, small interfering RNA; PiRNA, Piwi-interacting RNA; lncRNA, long noncoding RNA.
Figure 2
Figure 2
The image illustrates the classification and function of circRNAs.
See this image and copyright information in PMC

References

    1. Maron B.J., Towbin J.A., Thiene G., Antzelevitch C., Corrado D., Arnett D., Moss A.J., Seidman C.E., Young J.B. Contemporary definitions and classification of the cardiomyopathies: An American Heart Association scientific statement from the council on clinical cardiology, heart failure and transplantation committee; quality of care and outcomes research and functional genomics and translational biology interdisciplinary working groups; and council on epidemiology and prevention. Circulation. 2006;113:1807–1816. - PubMed
    1. Beqqali A. Alternative splicing in cardiomyopathy. Biophys. Rev. 2018;10:1061–1071. doi: 10.1007/s12551-018-0439-y. - DOI - PMC - PubMed
    1. Virani S.S., Alonso A., Aparicio H.J., Benjamin E.J., Bittencourt M.S., Callaway C.W., Carson A.P., Chamberlain A.M., Cheng S., Delling F.N., et al. Heart disease and stroke statistics—2021 update: A report from the American Heart Association. Circulation. 2021;143:e254–e743. - PubMed
    1. Braunwald E. Cardiomyopathies: An overview. Circ. Res. 2017;121:711–721. doi: 10.1161/CIRCRESAHA.117.311812. - DOI - PubMed
    1. Salemi V.M.C., Mohty D., Altavila S.L., Melo M.D., Kalil Filho R., Bocchi E.A. Insights into the Classification of Cardiomyopathies: Past, Present, and Future Directions. SciELO Bras. 2021;76:e2808. doi: 10.6061/clinics/2021/e2808. - DOI - PMC - PubMed

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