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Meta-Analysis
. 2022 Sep 3;13(9):1584.
doi: 10.3390/genes13091584.

Hip Osteoarthritis and the Risk of Lacunar Stroke: A Two-Sample Mendelian Randomization Study

Yi Shen  1 , Fuju Li  1 , Lina Cao  1 , Yunyun Wang  1 , Jing Xiao  1 , Xiaoyi Zhou  2 , Tian Tian  1
Affiliations
Meta-Analysis

Hip Osteoarthritis and the Risk of Lacunar Stroke: A Two-Sample Mendelian Randomization Study

Yi Shen et al. Genes (Basel). .

Abstract

Whether hip osteoarthritis (OA) could increase the risk of lacunar stroke (LS) is not well understood. This two-sample Mendelian randomization (MR) study aimed to investigate in depth the effect of genetically predicted hip OA on LS risk. Hip OA-related instrumental variables (IVs) were selected from a genome-wide association study (GWAS) of 393,873 individuals. The summary data of LS were obtained from a GWAS meta-analysis, including 16,030 cases and 248,929 controls. We used the inverse-variance weighted (IVW) as the primary MR analysis method. Moreover, the weighted-median, MR-Egger regression, and the MR pleiotropy residual sum and outlier (MR-PRESSO) test were supplementary methods. The sensitivity analysis was performed using the leave-one-out test. We identified the positive causal relationship between hip OA and the risk of LS (odds ratio [OR] = 1.20, 95% confidence interval [CI]: 1.07, 1.36; p = 0.002 using the IVW method). The weighted median method provided similar results. There was no evidence of directed pleiotropy, and sensitivity analysis results were stable, suggesting the robustness of our study. This study showed a causal effect of hip OA on the risk of LS, and more efforts should be made to explore the potential mechanisms in the future.

Keywords: Mendelian randomization; genome-wide association studies; hip osteoarthritis; lacunar stroke; single-nucleotide polymorphism.

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Conflict of interest statement

The authors have declared that no conflict of interest exists.

Figures

Figure 1
Figure 1
Design flow chart of the present study. Assumption 1: Instrumental variables should be robustly associated with exposure. Assumption 2: Instrumental variables should not be associated with any confounders. Assumption 3: Instrumental variables influence the outcome through the exposure, not through other pathways.
Figure 2
Figure 2
Scatter plots showed the causal effect of hip osteoarthritis on lacunar stroke. SNP, single nucleotide polymorphism; MR, Mendelian randomization.
Figure 3
Figure 3
Forrest plots of the causal effects of hip osteoarthritis associated SNPs on lacunar stroke.
Figure 4
Figure 4
Funnel plot showed no significant heterogeneity among the SNPs. SE, standard error.
See this image and copyright information in PMC

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