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Review
. 2022 Sep 13;13(9):1643.
doi: 10.3390/genes13091643.

Interleukin-17 Family Cytokines in Metabolic Disorders and Cancer

Eileen Victoria Meehan  1 , Kepeng Wang  1
Affiliations
Review

Interleukin-17 Family Cytokines in Metabolic Disorders and Cancer

Eileen Victoria Meehan et al. Genes (Basel). .

Abstract

Interleukin-17 (IL-17) family cytokines are potent drivers of inflammatory responses. Although IL-17 was originally identified as a cytokine that induces protective effects against bacterial and fungal infections, IL-17 can also promote chronic inflammation in a number of autoimmune diseases. Research in the last decade has also elucidated critical roles of IL-17 during cancer development and treatment. Intriguingly, IL-17 seems to play a role in the risk of cancers that are associated with metabolic disorders. In this review, we summarize our current knowledge on the biochemical basis of IL-17 signaling, IL-17's involvement in cancers and metabolic disorders, and postulate how IL-17 family cytokines may serve as a bridge between these two types of diseases.

Keywords: cancer; inflammation; interleukin-17; metabolic disorders.

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Conflict of interest statement

The authors declare no conflicts of interest.

Figures

Figure 1
Figure 1
How IL-17 promotes cancer development.
Figure 2
Figure 2
IL-17 bridges metabolic disorders and cancer.
See this image and copyright information in PMC

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