Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2022 Sep 7;23(18):10284.
doi: 10.3390/ijms231810284.

Marine Compounds for Melanoma Treatment and Prevention

Eleonora Montuori  1   2 , Anita Capalbo  2 , Chiara Lauritano  2
Affiliations
Review

Marine Compounds for Melanoma Treatment and Prevention

Eleonora Montuori et al. Int J Mol Sci. .

Abstract

Melanoma is considered a multifactorial disease etiologically divided into melanomas related to sun exposure and those that are not, but also based on their mutational signatures, anatomic site, and epidemiology. The incidence of melanoma skin cancer has been increasing over the past decades with 132,000 cases occurring globally each year. Marine organisms have been shown to be an excellent source of natural compounds with possible bioactivities for human health applications. In this review, we report marine compounds from micro- and macro-organisms with activities in vitro and in vivo against melanoma, including the compound Marizomib, isolated from a marine bacterium, currently in phase III clinical trials for melanoma. When available, we also report active concentrations, cellular targets and mechanisms of action of the mentioned molecules. In addition, compounds used for UV protection and melanoma prevention from marine sources are discussed. This paper gives an overview of promising marine molecules which can be studied more deeply before clinical trials in the near future.

Keywords: anti-cancer; marine biotechnology; melanoma; microalgae.

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
PubMed search results 2011–2021 by using as filters (a) the words “marine natural products” and (b) “melanoma“ and “marine natural products” in “all fields” query box.
Figure 2
Figure 2
Effects of UV light exposure.
Figure 3
Figure 3
Chemical structure (a) 2D and (b) 3D of Porphyra-334 (PubChem Identifier: CID 6857486) from https://pubchem.ncbi.nlm.nih.gov/compound/Porphyra-334#section=2D-Structure&fullscreen=true and https://pubchem.ncbi.nlm.nih.gov/compound/Porphyra-334#section=3D-Conformer&fullscreen=true, respectively (accessed on 13 July 2022) [100].
Figure 4
Figure 4
Chemical structure (a) 2D and (b) 3D of Marizomib (PubChem Identifier: CID 11347535) from https://pubchem.ncbi.nlm.nih.gov/compound/11347535#section=2D-Structure&fullscreen=true and https://pubchem.ncbi.nlm.nih.gov/compound/11347535#section=3D-Conformer&fullscreen=true, respectively (accessed on 13 July 2022) [135].
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

References

    1. Schneider S.H., Mastrandrea M.D., editors. Encyclopedia of Climate and Weather. 2nd ed. Oxford University Press; Oxford, UK: New York, NY, USA: 2011.
    1. Rastrelli M., Tropea S., Rossi C.R., Alaibac M. Melanoma: Epidemiology, Risk Factors, Pathogenesis, Diagnosis and Classification. In Vivo. 2014;28:1005–1011. - PubMed
    1. Islami F., Sauer A.G., Miller K.D., Fedewa S.A., Minihan A.K., Geller A.C., Lichtenfeld J.L., Jemal A. Cutaneous Melanomas Attributable to Ultraviolet Radiation Exposure by State. Int. J. Cancer. 2020;147:1385–1390. doi: 10.1002/ijc.32921. - DOI - PubMed
    1. Landi M.T., Bishop D.T., MacGregor S., Machiela M.J., Stratigos A.J., Ghiorzo P., Brossard M., Calista D., Choi J., Fargnoli M.C., et al. Genome-Wide Association Meta-Analyses Combining Multiple Risk Phenotypes Provide Insights into the Genetic Architecture of Cutaneous Melanoma Susceptibility. Nat. Genet. 2020;52:494–504. doi: 10.1038/s41588-020-0611-8. - DOI - PMC - PubMed
    1. Elder D.E., Bastian B.C., Cree I.A., Massi D., Scolyer R.A. The 2018 World Health Organization Classification of Cutaneous, Mucosal, and Uveal Melanoma: Detailed Analysis of 9 Distinct Subtypes Defined by Their Evolutionary Pathway. Arch. Pathol. Lab. Med. 2020;144:500–522. doi: 10.5858/arpa.2019-0561-RA. - DOI - PubMed