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Review
. 2022 Sep 8;23(18):10373.
doi: 10.3390/ijms231810373.

The Role of DNA Methylation in Stroke Recovery

Dong-Hee Choi  1   2 , In-Ae Choi  1   3 , Jongmin Lee  1   4
Affiliations
Review

The Role of DNA Methylation in Stroke Recovery

Dong-Hee Choi et al. Int J Mol Sci. .

Abstract

Epigenetic alterations affect the onset of ischemic stroke, brain injury after stroke, and mechanisms of poststroke recovery. In particular, DNA methylation can be dynamically altered by maintaining normal brain function or inducing abnormal brain damage. DNA methylation is regulated by DNA methyltransferase (DNMT), which promotes methylation, DNA demethylase, which removes methyl groups, and methyl-cytosine-phosphate-guanine-binding domain (MBD) protein, which binds methylated DNA and inhibits gene expression. Investigating the effects of modulating DNMT, TET, and MBD protein expression on neuronal cell death and neurorepair in ischemic stroke and elucidating the underlying mechanisms can facilitate the formulation of therapeutic strategies for neuroprotection and promotion of neuronal recovery after stroke. In this review, we summarize the role of DNA methylation in neuroprotection and neuronal recovery after stroke according to the current knowledge regarding the effects of DNA methylation on excitotoxicity, oxidative stress, apoptosis, neuroinflammation, and recovery after ischemic stroke. This review of the literature regarding the role of DNA methylation in neuroprotection and functional recovery after stroke may contribute to the development and application of novel therapeutic strategies for stroke.

Keywords: DNA methylation; epigenetics; neuroprotection; neurorepair; recovery; stroke; treatment.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
The flowchart of database searching, screening, selection, and inclusion of eligible articles from the literature.
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