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Review
. 2022 Sep 10;23(18):10521.
doi: 10.3390/ijms231810521.

Significance of Capping Agents of Colloidal Nanoparticles from the Perspective of Drug and Gene Delivery, Bioimaging, and Biosensing: An Insight

Rabia Javed  1   2 , Anila Sajjad  2 , Sania Naz  2 , Humna Sajjad  2 , Qiang Ao  1
Affiliations
Review

Significance of Capping Agents of Colloidal Nanoparticles from the Perspective of Drug and Gene Delivery, Bioimaging, and Biosensing: An Insight

Rabia Javed et al. Int J Mol Sci. .

Abstract

The over-growth and coagulation of nanoparticles is prevented using capping agents by the production of stearic effect that plays a pivotal role in stabilizing the interface. This strategy of coating the nanoparticles' surface with capping agents is an emerging trend in assembling multipurpose nanoparticles that is beneficial for improving their physicochemical and biological behavior. The enhancement of reactivity and negligible toxicity is the outcome. In this review article, an attempt has been made to introduce the significance of different capping agents in the preparation of nanoparticles. Most importantly, we have highlighted the recent progress, existing roadblocks, and upcoming opportunities of using surface modified nanoparticles in nanomedicine from the drug and gene delivery, bioimaging, and biosensing perspectives.

Keywords: biosensing; capping agents; diagnostics; drug delivery; nanoparticles; therapeutics.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Different types of capping agents along with examples.
Figure 2
Figure 2
Simplified mechanism of drug delivery mediated by capped nanoparticles.
Figure 3
Figure 3
Possible mechanism of gene delivery mediated by capped nanoparticles.
Figure 4
Figure 4
The capped nanoparticles used in various types of bioimaging.
Figure 5
Figure 5
Basic components of biosensors.
Figure 6
Figure 6
The capped nanoparticles used in biosensing.
See this image and copyright information in PMC

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